{"id":3377,"date":"1994-01-01T00:00:00","date_gmt":"1994-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1994\/01\/01\/estudios-preclinicos-con-nuevos-derivados-de-platino-posible-correlacion-y-extrapolacion-de-los-resultados-experimentales-a-humanos\/"},"modified":"1994-01-01T00:00:00","modified_gmt":"1994-01-01T00:00:00","slug":"estudios-preclinicos-con-nuevos-derivados-de-platino-posible-correlacion-y-extrapolacion-de-los-resultados-experimentales-a-humanos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudios-preclinicos-con-nuevos-derivados-de-platino-posible-correlacion-y-extrapolacion-de-los-resultados-experimentales-a-humanos\/","title":{"rendered":"Estudios preclinicos con nuevos derivados de platino. posible correlacion y extrapolacion de los resultados experimentales a humanos."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Frederic Sampedro Camarena <\/strong><\/h2>\n<p>La introduccion del cisplatino y del carboplatino en la quimioterapia del cancer y sobre todo los resultados obtenidos ha hecho posible que la busqueda de nuevos analogos de platino con un futuro terapeutico mas prometedor se encuentre en continua evolucion a pesar de no existir una metodolog\u00eda especifica que permita realizar los estudios preclinicos con estos nuevos agentes antitumorales. La consecucion de un modelo experimental aplicable a los estudios preclinicos con los derivados de platino ha sido de gran utilidad para poder correlacionar y extrapolar los resultados obtenidos en los diferentes estudios \u00abin vitro\u00bb e \u00abin vivo\u00bb realizados con mas de 50 nuevos derivados de platino. Se ha demostrado una buena correlacion entre los resultados obtenidos en: a)estudios de viabilidad celular en e.  coli. B) estudios de citotoxicidad en celulas tumorales del tipo leucemia l1210. C) estudios de toxicidad aguda en ratones bdf1. D) estudios de actividad antitumoral en ratones bdf1 portadores de celulas tumorales del tipo leucemia l1210. Tambien se ha demostrado la existencia de una buena correlacion y extrapolacion de los resultados experimentales a humanos mediante la aplicacion de los modelos alometricos pero no con los modelos farmacocineticos debido a la falta de unificacion de criterios y parametros.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudios preclinicos con nuevos derivados de platino. posible correlacion y extrapolacion de los resultados experimentales a humanos.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudios preclinicos con nuevos derivados de platino. posible correlacion y extrapolacion de los resultados experimentales a humanos. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Frederic Sampedro Camarena <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1994<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Eduardo Diogene Fadini<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francesc Jan\u00e9 Carrenca <\/li>\n<li>Roman Perez Soler (vocal)<\/li>\n<li>Francesc Xavier Carne Cladellas (vocal)<\/li>\n<li>Francesc Gonz\u00e1lez Sastre (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Frederic Sampedro Camarena La introduccion del cisplatino y del carboplatino en la quimioterapia del cancer y sobre [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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