{"id":33807,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-estructural-y-funcional-de-la-proteina-de-14kda-orf-a27l-del-virus-vaccinia-implicada-en-la-interaccion-virus-celula\/"},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"caracterizacion-estructural-y-funcional-de-la-proteina-de-14kda-orf-a27l-del-virus-vaccinia-implicada-en-la-interaccion-virus-celula","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/caracterizacion-estructural-y-funcional-de-la-proteina-de-14kda-orf-a27l-del-virus-vaccinia-implicada-en-la-interaccion-virus-celula\/","title":{"rendered":"Caracterizacion estructural y funcional de la proteina de 14kda (orf a27l) del virus vaccinia implicada en la interaccion virus-celula."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Vazquez Calleja M. Isabel <\/strong><\/h2>\n<p>El virus vaccinia (vv) es el nombre que se asign\u00f3 al agente utilizado para la vacunaci\u00f3n contra el virus de la viruela humana, uno de los agentes infecciosos m\u00e1s devastadores de la humanidad. Desde la erradicaci\u00f3n de la viruela, este virus est\u00e1 siendo considerado como alternativa para el desarrollo de vacunas contra una gran variedad de agentes infecciosos, gracias a su capacidad para integrar y expresar hasta 25.000 pares de bases de informaci\u00f3n heter\u00f3loga. Tambi\u00e9n constituye un modelo para el estudio de mecanismos de replicaci\u00f3n virales y de la biolog\u00eda celular. Sin embargo, se hace necesario un mayor conocimiento de los genes implicados en la entrada del virus, ciclo replicativo, virulencia y respuesta inmune, entre otros.  de las aproximadamente 100 prote\u00ednas que est\u00e1n implicadas en el ensamblaje del vv, la prote\u00edna de 14kda producto del gen a27l (p14) se ha considerado de gran importancia ya que est\u00e1 implicada en procesos de entrada y de salida del virus de la c\u00e9lula hospedadora, adem\u00e1s de ser altamente inmunog\u00e9nica e inducir la formaci\u00f3n de anticuerpos neutralizantes. Por todo ello realizamos una caracterizaci\u00f3n estructural y funcional de esta prote\u00edna de 110 amino\u00e1cidos.  de los estudios llevados a cabo hemos podido concluir:  1.- La prote\u00edna forma tr\u00edmeros de id\u00e9nticas subunidades mantenida por interacciones hidr\u00f3fobas y electrost\u00e1ticas, formando una estructura tipo coiled-coil (o de alfa-h\u00e9lices enrolladas sobre s\u00ed mismas formando una superh\u00e9lice). La viabilidad de esta estructura ha sido corroborada mediante la obtenci\u00f3n de un modelo tridimensional y din\u00e1mica molecular.  2.- En las part\u00edculas v\u00edricas, el extremo carboxilo de la p14 est\u00e1 implicado en la interacci\u00f3n con la prote\u00edna de 21kda. Esta \u00faltima es una prote\u00edna transmembrana que se localiza en la membrana v\u00edrica y que sirve de anclaje de la p14 a la superficie del virus maduro intracelular.  3.- En el extremo amino de la<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizacion estructural y funcional de la proteina de 14kda (orf a27l) del virus vaccinia implicada en la interaccion virus-celula.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizacion estructural y funcional de la proteina de 14kda (orf a27l) del virus vaccinia implicada en la interaccion virus-celula. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Vazquez Calleja M. Isabel <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda no Esteban Rodriguez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Manuel Freire Rama <\/li>\n<li>Jos\u00e9 Antonio Melero Fondevilla (vocal)<\/li>\n<li> Bernardez Hermida Mar\u00eda  Isabel (vocal)<\/li>\n<li>Juan Ortin Monton (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Vazquez Calleja M. Isabel El virus vaccinia (vv) es el nombre que se asign\u00f3 al agente utilizado [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[160,115,35,17,977,280,41329],"tags":[91897,14396,14725,2963,23995,91896],"class_list":["post-33807","post","type-post","status-publish","format-standard","hentry","category-bioquimica","category-bioquimica-molecular","category-ciencias-de-la-vida","category-quimica","category-santiago-de-compostela","category-virologia","category-virus-dermatropicos","tag-bernardez-hermida-maria-isabel","tag-jose-antonio-melero-fondevilla","tag-juan-ortin-monton","tag-manuel-freire-rama","tag-maria-no-esteban-rodriguez","tag-vazquez-calleja-m-isabel"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/33807","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=33807"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/33807\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=33807"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=33807"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=33807"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}