{"id":33814,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/contribucion-al-estudio-de-anticuerpos-en-hemostasia-anticuerpos-anticardiolipina-aca-y-anti-factor-viii\/"},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"contribucion-al-estudio-de-anticuerpos-en-hemostasia-anticuerpos-anticardiolipina-aca-y-anti-factor-viii","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/contribucion-al-estudio-de-anticuerpos-en-hemostasia-anticuerpos-anticardiolipina-aca-y-anti-factor-viii\/","title":{"rendered":"Contribucion al estudio de anticuerpos en hemostasia: anticuerpos anticardiolipina (aca) y anti-factor viii."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Pilar Vila Enriquez <\/strong><\/h2>\n<p>La presencia de anticuerpos naturales, anticuerpos anti-idiotipo o anticuerpos patol\u00f3gicos tiene gran relevancia en diversos campos de la hemostasia, entre otros podemos destacar su papel en: patolog\u00eda relacionada con el factor viii, hemof\u00edlia y s\u00edndrome antifosfol\u00edpido primario.  en la presente tesis se investigaron los siguientes aspectos:  1. PreValencia, seguimiento y significado cl\u00ednico de los anticuerpos anticardiolipina (aca) en sujetos normales.  1.1. La preValencia de aca igg en nuestra poblaci\u00f3n era de 6.5% y la de aca igm 9.4%.  1.2. No se observ\u00f3 relaci\u00f3n entre los donantes aca positivos y los datos cl\u00ednicos y de laboratorio estudiados.  1.3. No encontramos relaci\u00f3n entre aca y al.  1.4. Creemos que el al y aca identifican distintos autoanticuerpos, por tanto deben realizarse ambos cuando se sospeche aaf.  1.5. No tenemos datos cl\u00ednicos ni de laboratorio que nos expliquen las positividades encontradas en los donantes y desconocemos si en el futuro desarrollar\u00e1n alguna complicaci\u00f3n tromboemb\u00f3lica, o si estamos ante la primera manifestaci\u00f3n de una enfermedad autoinmune.  2. Anticuerpos anti-factor viii(fviii-ac) en el plasma de pacientes con hemofilia a y en individuos sanos.  2.1. El m\u00e9todo elisa descrito es eficiente para detectar fviii-ac espec\u00edficos en el plasma.  2.2. Se encontraron fviii-ac en el plasma de 15% de los donantes, similar a lo previamente publicado.  2.3. Observamos un 27% de fviii-ac en pacientes con hemofilia a.  2.4. En los pacientes con hemofilia a e historia de inhibidor exist\u00eda una fuerte correlaci\u00f3n entre el nivel de fviii-ac y el t\u00edtulo de unidades bethesda (ub) correspondiente.  2.5. La media de edad de los pacientes con fviii-ac positivo era mayor que la del grupo negativo. La media de edad del inicio del tratamiento sustitutivo era menor en pacientes fviii-ac negativos. En el grupo hiv+ la proporci\u00f3n de pacientes severos era el doble que en los hiv-.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Contribucion al estudio de anticuerpos en hemostasia: anticuerpos anticardiolipina (aca) y anti-factor viii.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Contribucion al estudio de anticuerpos en hemostasia: anticuerpos anticardiolipina (aca) y anti-factor viii. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Pilar Vila Enriquez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisco Javier Batlle Fontrodona<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Emilio Barrio Gomez <\/li>\n<li>Angel Mar\u00eda Carracedo Alvarez (vocal)<\/li>\n<li>Angeles Rodriguez Santamarta (vocal)<\/li>\n<li>Antonio Lopez Borrasca (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Pilar Vila Enriquez La presencia de anticuerpos naturales, anticuerpos anti-idiotipo o anticuerpos patol\u00f3gicos tiene gran relevancia en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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