{"id":33876,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-del-efecto-embriotoxico-de-la-vinorelbina-en-el-embrion-de-ave\/"},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"estudio-del-efecto-embriotoxico-de-la-vinorelbina-en-el-embrion-de-ave","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/estudio-del-efecto-embriotoxico-de-la-vinorelbina-en-el-embrion-de-ave\/","title":{"rendered":"Estudio del efecto embriotoxico de la vinorelbina en el embrion de ave."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Fernandez Montes Antonio  Jes\u00fas <\/strong><\/h2>\n<p>Se efect\u00faa un estudio experimental del efecto embriot\u00f3xico de la vinorelbina, para lo cual se utilizan 400 embriones de pollo raza \u00ablegorn blanca\u00bb, divididos en 4 series de 100 embriones cada una. Los ejemplares utilizados quedan enmarcados en los estadios de desarrollo 10, 14, 18 y 22 de hamburger-hamilton. Se inyectaron cuatro dosis diferentes para cada estadio.  tras el estudio macro y microsc\u00f3pico mediante cortes seriados de los embriones supervivientes se obtuvieron unos resultados que finalmente aportan las siguientes conclusiones:  1.- La vinorelbina en nuestro trabajo de investigaci\u00f3n, se ha mostrado como un agente altamente embriot\u00f3xico y escasamente embrioletal a las dosis terap\u00e9uticas por extrapolaci\u00f3n.  2.- Podemos establecer la dosis letal 50 en 10 mcl para el estadio 10 de hamburger-hamilton de desarrollo, siendo sensiblemente superior y de forma progresiva para los estadios 14, 18 y 22 de hamburger-hamilton.  3.- Podemos designar el estadio 10 de hamburger-hamilton de desarrollo, como el de mayor incidencia embriot\u00f3xica, disminuyendo la embriotoxicidad al aumentar el estadio para una misma dosis. La vinorelbina se ha mostrado, pues, como un agente estadio-dependiente.  4.- La microsom\u00eda fue la alteraci\u00f3n m\u00e1s frecuentemente observada, acaeciendo en la pr\u00e1ctica totalidad de los embriones tratados.  5.- Las malformaciones organog\u00e9nicas que aparecieron con mayor frecuencia, fueron la microcefalia y las lesiones oft\u00e1lmicas, cuya tasa de incidencia se centr\u00f3 en los estadios 10 y 14 de hamburger-hamilton de desarrollo, disminuyendo dr\u00e1sticamente su incidencia en los estadios 18 y 22 de hamburger-hamilton; y en el caso de la microcefalia, desapareciendo su incidencia.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio del efecto embriotoxico de la vinorelbina en el embrion de ave.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio del efecto embriotoxico de la vinorelbina en el embrion de ave. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Fernandez Montes Antonio  Jes\u00fas <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Granada<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Barranco Zafra Rafael Jes\u00fas<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  De Dios Garc\u00eda Garc\u00eda <\/li>\n<li>Jos\u00e9 Francisco Rodr\u00edguez V\u00e1zquez (vocal)<\/li>\n<li>Pascual Vicente Crespo Ferrer (vocal)<\/li>\n<li>Javier Ca\u00f1izares Garcia (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Fernandez Montes Antonio Jes\u00fas Se efect\u00faa un estudio experimental del efecto embriot\u00f3xico de la vinorelbina, para lo [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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