{"id":34006,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efectos-farmacologicos-del-extracto-de-polypodium-leucotomos-en-un-modelo-experimental-de-inflamacion-intestinal\/"},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"efectos-farmacologicos-del-extracto-de-polypodium-leucotomos-en-un-modelo-experimental-de-inflamacion-intestinal","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/efectos-farmacologicos-del-extracto-de-polypodium-leucotomos-en-un-modelo-experimental-de-inflamacion-intestinal\/","title":{"rendered":"Efectos farmacologicos del extracto de polypodium leucotomos en un modelo experimental de inflamacion intestinal."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Romero Garrido Jos\u00e9 Antonio <\/strong><\/h2>\n<p>El extracto de polypodium leucotomos, ha ejercido efectos beneficiosos en patolog\u00edas de la piel como la psoriasis, dermatitis at\u00f3pica, etc. Estas patolog\u00edas se caracterizan por presentar una etiolog\u00eda desconocida, a\u00fanque se encuentran alteradas la respuesta inmune\/inflamatoria.  este extracto se caracteriza por presentar un efecto inmunomodulador y antiinflamatorio, por lo que hemos estudiado su posible actividad antiinflamatoria en un modelo experimental de inflamaci\u00f3n intestinal, intentando simular la enfermedad inflamatoria intestinal que tiene lugar en humanos. Este estudio se ha realizado entres fases:  1.- Estudio preventivo frente a la fase aguda de la inflamaci\u00f3n, obteniendose un efecto beneficioso que se manifest\u00f3 por una actividad preventiva frente a la inflaci\u00f3n provocada por tnbs\/etanol. El efecto beneficioso obtenido se tradujo en una mejora de la funcionalidad intestinal, as\u00ed, como en una inhibici\u00f3n de la s\u00edntesis col\u00f3nica de leucotrieno b4 y una normalizaci\u00f3n en el contenido col\u00f3nico de glutation.  2.- En la segunda fase se estudi\u00f3 el efecto curativo frente al desarrollo cr\u00f3nico de la inflamaci\u00f3n provocada de forma similar a la fase aguda; el efecto obtenido fu\u00e9 una sustancial mejoria que se manifest\u00f3 en la tercera semana de iniciado el experimento, obteniendose un incremento en la absorci\u00f3n de agua por parte del intestino grueso.  3.- En la tercera fase se estudi\u00f3 el efecto frente a un modelo experimental de recurrencias, intentando simular los per\u00edodos de mayor gravedad caracteristicos de estas patolog\u00edas. Para ello se realiz\u00f3 una administraci\u00f3n intermitente de tnbs\/etanol con un intervalo de dos semanas. El efecto obtenido tras el tratamiento con el extracto fu\u00e9 una normalizaci\u00f3n de la funcionalidad intestinal, as\u00ed como una inhibici\u00f3n de la s]ntesis col\u00f3nica de leucotrieno b4 despu\u00e9s de inducida la recurrencia.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efectos farmacologicos del extracto de polypodium leucotomos en un modelo experimental de inflamacion intestinal.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efectos farmacologicos del extracto de polypodium leucotomos en un modelo experimental de inflamacion intestinal. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Romero Garrido Jos\u00e9 Antonio <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Granada<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Zarzuelo Zurita<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Gassull I Duro Miguel Angel <\/li>\n<li>Jos\u00e9 Luis Rios Ca\u00f1avate (vocal)<\/li>\n<li>Francisco Zaragoza Garcia (vocal)<\/li>\n<li>Severiano Risco Acedo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Romero Garrido Jos\u00e9 Antonio El extracto de polypodium leucotomos, ha ejercido efectos beneficiosos en patolog\u00edas de la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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