{"id":34170,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-primoinfeccion-in-vivo-por-sivmac-en-el-sistema-linfoide-de-macacos-cynomolgus-macaca-fascicularis-mediante-hibridacion-in-situ\/"},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"estudio-de-la-primoinfeccion-in-vivo-por-sivmac-en-el-sistema-linfoide-de-macacos-cynomolgus-macaca-fascicularis-mediante-hibridacion-in-situ","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-de-la-primoinfeccion-in-vivo-por-sivmac-en-el-sistema-linfoide-de-macacos-cynomolgus-macaca-fascicularis-mediante-hibridacion-in-situ\/","title":{"rendered":"Estudio de la primoinfeccion in vivo por sivmac en el sistema linfoide de macacos cynomolgus (macaca fascicularis) mediante hibridacion in situ."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Carmen Canto Nogues <\/strong><\/h2>\n<p>Se ha estudiado y caracterizado, en macacos cynomolgus, el inicio de la infecci\u00f3n in vivo por dos clones distintos de sivmac: uno virulento, clon j5, y otro su hom\u00f3logo atenuado, clon c8. Para ello se han empleado secciones de distintos \u00f3rganos (principalmente linfoides) fijados con formaldeh\u00eddo e incluidos en parafina, donde se han analizado qu\u00e9 c\u00e9lulas expresan arns v\u00edricos mediante hibridaci\u00f3n in situ (his) a distintos tiempos post-infecci\u00f3n, con cada uno de estos clones. El estudio revel\u00f3 que, a 7 d\u00edas post-infecci\u00f3n (d.P.I.), Son los ganglios linf\u00e1ticos mesent\u00e9ricos asociados al tracto digestivo, los que presentan mayor expresi\u00f3n de arns v\u00edricos en los animales infectados con uno u otro clon.  la comparaci\u00f3n posterior de los resultados de his con los de inmunomarcado (inm) de prote\u00ednas v\u00edricas, especialmente con el inm de la prote\u00edna nef, sugiere que esta prote\u00edna, en el caso de c8, no act\u00faa de modo adecuado en la morfog\u00e9nesis de viriones con car\u00e1cter infeccioso, debido a que debe ser inestable y no alcanza niveles suficientes para llevar a cabo su funci\u00f3n.  tambi\u00e9n se observa distinto grado de activaci\u00f3n de las poblaciones celulares de macr\u00f3fagos y c\u00e9lulas dendr\u00edtico-foliculares, seg\u00fan el clon que haya infectado el animal. El estudio de la expresi\u00f3n de las citoquinas il4 y ifngamma por his mostr\u00f3 a 14 d.P.I. En la infecci\u00f3n por c8, que los arns de \u00e9stas son muy abundantes en el bazo, en relaci\u00f3n a la infecci\u00f3n por j5, y que ello pod\u00eda deberse a que c8 activa de forma m\u00e1s eficaz a las c\u00e9lulas t que j5. Finalmente, la detecci\u00f3n de c\u00e9lulas en proceso de apoptosis por tanel no pudo confirmar la existencia de un mayor n\u00famero de c\u00e9lulas en apoptosis en los tejidos linfoides de animales infectados con j5 que con c8.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la primoinfeccion in vivo por sivmac en el sistema linfoide de macacos cynomolgus (macaca fascicularis) mediante hibridacion in situ.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la primoinfeccion in vivo por sivmac en el sistema linfoide de macacos cynomolgus (macaca fascicularis) mediante hibridacion in situ. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Carmen Canto Nogues <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Herrera Calvet M. Inmaculada<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Guillermo Suarez Fernandez <\/li>\n<li>Mar\u00eda no Esteban Rodriguez (vocal)<\/li>\n<li>Patricio Gonz\u00e1lez Valverde (vocal)<\/li>\n<li>Esteban Domingo Solans (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Carmen Canto Nogues Se ha estudiado y caracterizado, en macacos cynomolgus, el inicio de la infecci\u00f3n in [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[155,35,9,278,597],"tags":[92472,5645,284,92473,23995,56651],"class_list":["post-34170","post","type-post","status-publish","format-standard","hentry","category-ciencias-clinicas","category-ciencias-de-la-vida","category-ciencias-medicas","category-microbiologia","category-microbiologia-clinica","tag-carmen-canto-nogues","tag-esteban-domingo-solans","tag-guillermo-suarez-fernandez","tag-herrera-calvet-m-inmaculada","tag-maria-no-esteban-rodriguez","tag-patricio-gonzalez-valverde"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/34170","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=34170"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/34170\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=34170"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=34170"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=34170"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}