{"id":34210,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-de-la-ciclosporina-a-sobre-un-modelo-de-isquemia-reperfusion-intestinal-en-ratas\/"},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"efecto-de-la-ciclosporina-a-sobre-un-modelo-de-isquemia-reperfusion-intestinal-en-ratas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/efecto-de-la-ciclosporina-a-sobre-un-modelo-de-isquemia-reperfusion-intestinal-en-ratas\/","title":{"rendered":"Efecto de la ciclosporina a sobre un modelo de isquemia-reperfusion intestinal en ratas."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Angel Cuadrado Garcia <\/strong><\/h2>\n<p>La p\u00e9rdida de la funci\u00f3n de la barrera mucosa intestinal y la subsecuente translocaci\u00f3n bacteriana y endotoxemia han sido implicadas en el desarrollo de la infecci\u00f3n sist\u00e9mica. Es aceptado que la translocaci\u00f3n bacteriana puede tener un papel en la prolongaci\u00f3n y mantenimiento del shock s\u00e9ptico.  entre otros, la isquemia-reperfusi\u00f3n (i\/r) intestinal es uno de los factores patog\u00e9nicos m\u00e1s importantes que predisponen a la translocaci\u00f3n bacteriana. Por otra parte, en el da\u00f1o originado por la i\/r pueden tener un papel importante los polimorfonucleares (pmn). Ha sido descrito como la ciclosporina a (cs a) puede influir en la actividad de los pmn.  objetivo: estudiar un posible efecto beneficioso de la cs a en un modelo de i\/r intestinal.  material y m\u00e9todos: hemos utilizado ratas wistar macho de 250-300 g de peso, que se distribuyeron en cuatro grupos.  en el grupo 1, los animales se sometieron a un per\u00edodo de 60 minutos de isquemia intestinal por clampaje de la arteria mesent\u00e9rica superior. En el grupo 2, las ratas se sometieron al mismo tratamiento, excepto que se les administr\u00f3 cs a. Los grupos 3 y 4 (grupos control) se manipularon de forma similar a los anteriores pero sin ser sometidos a isquemia intestinal. Una hora despu\u00e9s de retirar el clamp, las ratas se sacrificaron para la obtenci\u00f3n de muestras de sangre de vena porta y vena cava, as\u00ed como de tejido hep\u00e1tico e intestinal.  resultados: la administraci\u00f3n de cs a indujo un aumento significativo en la supervivencia de los animales (77% vs 40%), bloque\u00f3 el aumento de los niveles de endotoxina circulantes inducidos por la i\/r (0,272 +-0,03 vs 0,69+-0,17 -cava-; 0,379+-0,15 vs 0,993+-0,07 -porta-; ui\/ml) la administraci\u00f3n de cs a tambi\u00e9n redujo significativamente el aumento de productos de peroxidaci\u00f3n lip\u00eddica inducida por la i\/r intestinal (4,783+-0,9 vs 10,03+-1,4 -cava-; 9,24 +-3,62 vs 16,1+-2,3 -porta-; nmol\/ml), y de \u00f3xido n\u00edtrico en vena cav<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto de la ciclosporina a sobre un modelo de isquemia-reperfusion intestinal en ratas.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto de la ciclosporina a sobre un modelo de isquemia-reperfusion intestinal en ratas. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Angel Cuadrado Garcia <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Luis Balibrea  Cantero<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jaime Arias Perez <\/li>\n<li>Miguel Angel Ca\u00ednzos Fern\u00e1ndez (vocal)<\/li>\n<li>Alberto Gomez Alonso (vocal)<\/li>\n<li>Elena Vara Ameigeiras (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Angel Cuadrado Garcia La p\u00e9rdida de la funci\u00f3n de la barrera mucosa intestinal y la subsecuente translocaci\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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