{"id":34213,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/modificaciones-en-la-actividad-y-expresion-de-la-sintasa-de-oxido-nitrico-en-la-dependencia-fisica-a-opiaceos\/"},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"modificaciones-en-la-actividad-y-expresion-de-la-sintasa-de-oxido-nitrico-en-la-dependencia-fisica-a-opiaceos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/modificaciones-en-la-actividad-y-expresion-de-la-sintasa-de-oxido-nitrico-en-la-dependencia-fisica-a-opiaceos\/","title":{"rendered":"Modificaciones en la actividad y expresion de la sintasa de oxido nitrico en la dependencia fisica a opiaceos."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Beatriz Cuellar Cerrillo <\/strong><\/h2>\n<p>Los mecanismos por los cuales se producen los fen\u00f3menos de tolerancia y abstinencia a opi\u00e1ceos no est\u00e1n a\u00fan totalmente aclarados. Se ha llamado la atenci\u00f3n sobre el papel de los amino\u00e1cidos excitadores (aae) en los procesos de tolerancia y dependencia. Concretamente, durante la abstinencia la liberaci\u00f3n de aae puede inducir activaci\u00f3n de la enzima formadora de \u00f3xido n\u00edtrico (no), la no sintasa (nos) y, consecuentemente, una sobreproducci\u00f3n de no. Sin embargo, falta estudios globales sobre los mecanismos por los cuales la administraci\u00f3n cr\u00f3nica de opi\u00e1ceos y la precipitaci\u00f3n de abstinencia modifican la producci\u00f3n de no. Nuestra hip\u00f3tesis es que durante la abstinencia opi\u00e1cea existe una sobreproducci\u00f3n de no que modifica la producci\u00f3n de segundos mensajeros y la liberaci\u00f3n de aae y catecolaminas. El prop\u00f3sito de esta tesis es estudiar c\u00f3mo se lleva a cabo la secuencia de acontecimientos antes y despu\u00e9s de la formaci\u00f3n de no en situaci\u00f3n de administraci\u00f3n cr\u00f3nica y en abstinencia. Para ello, se evaluan los cambios en la actividad nos, y su relaci\u00f3n con los s\u00edntomas de abstinencia en ratones. Las conclusiones m\u00e1s relevantes de esta tesis, son que durante el s\u00edndrome de abstinencia se produce un aumento de la actividad nos en el sistema nervioso central y que agentes que disminuyen la producci\u00f3n de no directa (l-name) o indirectamente (lamotrigina y dizolcipina) poseen propiedades anti-abstinencia.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Modificaciones en la actividad y expresion de la sintasa de oxido nitrico en la dependencia fisica a opiaceos.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Modificaciones en la actividad y expresion de la sintasa de oxido nitrico en la dependencia fisica a opiaceos. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Beatriz Cuellar Cerrillo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Leza Cerro Juan  Carlos<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Angel Fuentes Cubero <\/li>\n<li>Jos\u00e9 Rodrigo Garcia (vocal)<\/li>\n<li>Mar\u00eda  Isabel Martin Fontelles (vocal)<\/li>\n<li> Fernandez Tome M. Paz (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Beatriz Cuellar Cerrillo Los mecanismos por los cuales se producen los fen\u00f3menos de tolerancia y abstinencia a [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[7463,9,957,183,7464,324],"tags":[92542,55252,23352,14594,66204,6039],"class_list":["post-34213","post","type-post","status-publish","format-standard","hentry","category-abuso-de-drogas","category-ciencias-medicas","category-farmacologia","category-farmacos-psicotropicos","category-psicofarmacologia","category-psicologia","tag-beatriz-cuellar-cerrillo","tag-fernandez-tome-m-paz","tag-jose-angel-fuentes-cubero","tag-jose-rodrigo-garcia","tag-leza-cerro-juan-carlos","tag-maria-isabel-martin-fontelles"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/34213","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=34213"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/34213\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=34213"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=34213"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=34213"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}