{"id":34223,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/aloinmunotrasplante-de-nervio-periferico-tratado-con-fk-506\/"},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"aloinmunotrasplante-de-nervio-periferico-tratado-con-fk-506","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/aloinmunotrasplante-de-nervio-periferico-tratado-con-fk-506\/","title":{"rendered":"Aloinmunotrasplante de nervio periferico tratado con fk-506."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Marta Diez Angulo <\/strong><\/h2>\n<p>Durante el per\u00edodo de tiempo comprendido entre 1994 y 1997 se ha desarrollado un proyecto de investigaci\u00f3n que viene a completar los previamente llevados a cabo en el departamento de cirug\u00eda de la ucm. En un inicio de la investigaci\u00f3n se comprob\u00f3 que la criopreservaci\u00f3n no afectaba la regeneraci\u00f3n axonal en isotrasplantes. En un segundo tiempo se comprob\u00f3 que la estimulaci\u00f3n electromagn\u00e9tica mejoraba la regeneraci\u00f3n nerviosa perif\u00e9rica. Ahora se propon\u00eda demostrar que mediante un nuevo inmunosupresor el fk-506, era posible obtener una regeneraci\u00f3n axonal utilizando ratas como donantes tipo bn de barrera de histocompatibilidad elevada. Esta comprobaci\u00f3n se llev\u00f3 a cabo mediante histolog\u00eda simple, inmunohistoquimia, morfometr\u00eda axonal y electrofisiolog\u00eda. Comprob\u00e1ndose tras estos estudios que el grupo tratado obten\u00eda una mejora significativa en la regeneraci\u00f3n axonal cuando se compara con el control.  en el an\u00e1lisis inmunohistoqu\u00edmico del alotrasplante nervioso los animales no tratados presentan una marcada positividad para c\u00e9lulas relacionadas con el inicio del rechazo: macr\u00f3fagos, linfocitos t y ant\u00edgeno de identidad ia.  el marcaje para linfocitos cd 8 responsables del mantenimiento del rechazo, da una reacci\u00f3n inmunohistoqu\u00edmica muy positiva en el grupo control, tanto a las 5 como a las 11 semanas, objetiv\u00e1ndose por el contrario un marcaje progresivamente m\u00e1s d\u00e9bil en los animales tratados con fk-506 a medida que se prolonga la duraci\u00f3n del tratamiento lo que implica un menor rechazo y una mayor supervivencia del injerto.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Aloinmunotrasplante de nervio periferico tratado con fk-506.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Aloinmunotrasplante de nervio periferico tratado con fk-506. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Marta Diez Angulo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jaime Arias Perez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Hipolito Duran Sacristan <\/li>\n<li>Antonio Navarro Quilis (vocal)<\/li>\n<li>Luis Mar\u00eda Ferrandez Portal (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Marta Diez Angulo Durante el per\u00edodo de tiempo comprendido entre 1994 y 1997 se ha desarrollado un [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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