{"id":34322,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/funcion-de-los-polimorfonucleares-en-la-cirrosis-hepatica\/"},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"funcion-de-los-polimorfonucleares-en-la-cirrosis-hepatica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/funcion-de-los-polimorfonucleares-en-la-cirrosis-hepatica\/","title":{"rendered":"Funcion de los polimorfonucleares en la cirrosis hepatica."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Garfia Castillo M. Cristina <\/strong><\/h2>\n<p>Las infecciones constituyen una complicaci\u00f3n frecuente y grave de la cirrosis hep\u00e1tica. Se han observado diferentes alteraciones en los mecanismos de defensa de los pacientes cirr\u00f3ticos que podr\u00edan explicar la susceptibilidad a las infecciones. Entre estas se encuentran las disfunciones de los neutr\u00f3filos. La funci\u00f3n fundamental de los neutr\u00f3filos es la fagocitosis y la destrucci\u00f3n de los microorganismos. La actividad microbicida se realiza a trav\u00e9s de unos sistemas ox\u00edgeno-dependientes y ox\u00edgeno-independientes. Existen pocos estudios publicados sobre las alteraciones de estos mecanismos en los cirr\u00f3ticos. Nuestro trabajo ha pretendido conocer si en los pacientes con cirrosis hep\u00e1tica existe un defecto en el funcionalismo de los neutr\u00f3filos, en los mecanismos microbicidas ox\u00edgeno-dependientes, que los incapacite para destruir a las bacterias fagocitadas y, por tanto, que contribuya a aumentar la susceptibilidad a las infecciones. Adem\u00e1s, hemos intentado localizar el nivel donde se encuentra ese defecto y, finalmente establecer si existe alguna relaci\u00f3n con alguna caracter\u00edstica de la cirrosis.  nuestros resultados indican que existe un defecto intr\u00ednseco en la funci\u00f3n postfagoc\u00edtica en los neutr\u00f3filos de pacientes con cirrosis hep\u00e1tica que se expresa con una menor producci\u00f3n de ani\u00f3n super\u00f3xido.  dado que este defecto aparece al emplear est\u00edmulos vehiculizados por la prote\u00edna g, y no con est\u00edmulos no trasmitidos a trav\u00e9s de esta prote\u00edna g, probablemente se encuentre localizado en los mecanismos de activaci\u00f3n de membrana, y m\u00e1s concretamente a nivel de la prote\u00edna g.  tambi\u00e9n hemos observado que este defecto es independiente de la etiolog\u00eda de la cirrosis, no tiene relaci\u00f3n con los niveles de transaminasas, pero s\u00ed con el grado de insuficiencia hep\u00e1tica. Este trastorno pudiera contribuir a la mayor incidencia de infecciones en estos enfermos, en particular en los que presentan hemorragia di<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Funcion de los polimorfonucleares en la cirrosis hepatica.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Funcion de los polimorfonucleares en la cirrosis hepatica. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Garfia Castillo M. Cristina <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Antonio Solis  Herruzo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Rafael Enr\u00edquez De Salamanca <\/li>\n<li> Pajares Garc\u00eda Jos\u00e9 Mar\u00eda (vocal)<\/li>\n<li>Florinda Gilsanz Rodriguez (vocal)<\/li>\n<li>Agust\u00edn Albillos Mart\u00ednez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Garfia Castillo M. Cristina Las infecciones constituyen una complicaci\u00f3n frecuente y grave de la cirrosis hep\u00e1tica. Se [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,491,139],"tags":[31696,30150,92733,22624,7008,23210],"class_list":["post-34322","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-gastroenterologia","category-medicina-interna","tag-agustin-albillos-Martinez","tag-florinda-gilsanz-rodriguez","tag-garfia-castillo-m-cristina","tag-jose-antonio-solis-herruzo","tag-pajares-garcia-jose-maria","tag-rafael-enriquez-de-salamanca"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/34322","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=34322"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/34322\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=34322"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=34322"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=34322"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}