{"id":34346,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/expresion-de-la-oxido-nitrico-sintasa-inducible-en-la-pared-vascular-tras-denudacion-endotelial-por-balon-papel-de-las-plaquetas\/"},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"expresion-de-la-oxido-nitrico-sintasa-inducible-en-la-pared-vascular-tras-denudacion-endotelial-por-balon-papel-de-las-plaquetas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/expresion-de-la-oxido-nitrico-sintasa-inducible-en-la-pared-vascular-tras-denudacion-endotelial-por-balon-papel-de-las-plaquetas\/","title":{"rendered":"Expresion de la oxido nitrico sintasa inducible en la pared vascular tras denudacion endotelial por balon: papel de las plaquetas."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Fernando Gonzalez Fernandez <\/strong><\/h2>\n<p>En estudios in vitro realizados en nuestro laboratorio se observ\u00f3 que la expresi\u00f3n de la \u00f3xido n\u00edtrico sintasa inducible (nosi), en cultivos de c\u00e9lulas del m\u00fasculo liso incubadas con citoquinas, estaba disminuida en presencia de c\u00e9lulas endoteliales (ce). El objetivo de este estudio fue analizar la expresi\u00f3n de la nosi en la pared arterial en la desendotelizaci\u00f3n in vivo. La denudaci\u00f3n endotelial por bal\u00f3n (de) se realiz\u00f3 en la car\u00f3tida izquierda de ratas wistar (6 ratas por cada experimento). La expresi\u00f3n de la nosi se determin\u00f3 por western blot. La nosi estaba ligeramente expresada a las 6,24 y 48 horas despu\u00e9s de la de, sin embargo, se observ\u00f3 una gran expresi\u00f3n de la nosi a los 7, 14 y 30 d\u00edas tras la de. El siguiente objetivo fue analizar el papel de las plaquetas en la peque\u00f1a expresi\u00f3n de la nosi, observada inmediatamente despu\u00e9s de la de. Ratas trombocitop\u00e9nicas mostraron un aumento en la expresi\u00f3n de la nosi, en los primeros momentos tras la de (6 a 48 horas). El bloqueo de la glicoprote\u00edna iib\/iiia (gp iib\/iiia), por tratamiento con el anticuerpoabciximab aument\u00f3 al expresi\u00f3n de la nosi en los primeros momentos tras la de. Este resultado no se observ\u00f3 al usar una igg no espec\u00edfica. No obstante, el aumento de nosi encontrado en las ratas tratadas con abciximab fue menor que el obtenido en las ratas trombocitop\u00e9nicas. La administraci\u00f3n conjunta de un inhibidor de la gliceprote\u00edna ib (gp ib), el acido aurin-tricarbox\u00edlico (ata) y abciximab, se encontr\u00f3 que aumentaba la expresi\u00f3n de la nosi se expresa en la pared arterial varios d\u00edas despu\u00e9s de la de mientras que inmediatamente despu\u00e9s de la de s\u00f3lo se encuentra una ligera expresi\u00f3n de la nosi.  las plaquetas, a trav\u00e9s de un mecanismo dependiente de la gp iib\/iiia y del gp ib, juegan un papel importante en la disminuci\u00f3n de la expresi\u00f3n de la nosi despu\u00e9s de la de.  futuros estudios delimitar\u00e1n la importancia de favorecer la capac<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Expresion de la oxido nitrico sintasa inducible en la pared vascular tras denudacion endotelial por balon: papel de las plaquetas.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Expresion de la oxido nitrico sintasa inducible en la pared vascular tras denudacion endotelial por balon: papel de las plaquetas. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Fernando Gonzalez Fernandez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio L\u00f3pez Farr\u00e9<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  Luis Tamargo Men\u00e9ndez <\/li>\n<li>Jeronimo Farre Muncharaz (vocal)<\/li>\n<li>Manuel Oya Otero (vocal)<\/li>\n<li>Angel Celdran Uriarte (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Fernando Gonzalez Fernandez En estudios in vitro realizados en nuestro laboratorio se observ\u00f3 que la expresi\u00f3n de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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