{"id":34434,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/aportacion-del-estudio-de-los-reordenamientos-de-las-inmunoglobulinas-y-receptores-de-celulas-t-en-el-diagnostico-y-pronostico-de-la-leucemia-aguda-linfoblastica\/"},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"aportacion-del-estudio-de-los-reordenamientos-de-las-inmunoglobulinas-y-receptores-de-celulas-t-en-el-diagnostico-y-pronostico-de-la-leucemia-aguda-linfoblastica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/aportacion-del-estudio-de-los-reordenamientos-de-las-inmunoglobulinas-y-receptores-de-celulas-t-en-el-diagnostico-y-pronostico-de-la-leucemia-aguda-linfoblastica\/","title":{"rendered":"Aportacion del estudio de los reordenamientos de las inmunoglobulinas y receptores de celulas t en el diagnostico y pronostico de la leucemia aguda linfoblastica."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Montserrat Lopez Rubio <\/strong><\/h2>\n<p>Se estudia el estado de los genes de las inmunoglobulinas y receptores de c\u00e9lulas t, al diagn\u00f3stico y en remisi\u00f3n completa, mediante las t\u00e9cnicas de southern y reacci\u00f3n en cadena de la polimerasa en 35 pacientes diagnosticados de leucemia aguda linfobl\u00e1stica. Se valora la utilidad de los mismos en la definici\u00f3n de la linea celular, detecci\u00f3n de enfermedad m\u00ednima residual y su posible influencia pron\u00f3stica. Adem\u00e1s, se estudia la importancia pron\u00f3stica de los factores de riesgo cl\u00e1sico: edad, n\u00famero de leucocitos al diagn\u00f3stico, morfolog\u00eda, inmunofenotipo, cariotipo, tiempo en adquirir la remisi\u00f3n completa. Se estudia la presencia de oligoclonalidad las conclusiones son:  1.- Los reordenamientos no son espec\u00edficos de linea celular.  2.- Existe una asincron\u00eda entre reordenamientos y expresi\u00f3n de ant\u00edgenos de superficie.  3.- Alta incidencia de oligoclonalidad no transcendencia pron\u00f3stica.  4.- No existe buena correlaci\u00f3n entre detecci\u00f3n de emr y reca\u00edda.  5.- La edad es un factor con demostrado valor pron\u00f3stico, a favor de ni\u00f1os.  6.- La cifra de leucocitos influye en el tiempo en alcanzar la rc s\u00f3lo en adultos.  7.- La morfolog\u00eda l2 es de mal pron\u00f3stico s\u00f3lo en adultos.  8.- Los pacientes con fenotipo pre-pre-b y t tienen un riesgo de alcanzar la remisi\u00f3n completa en 4 semanas de 10 veces superior a los de fenotipo com\u00fan.  la supervivencia de los de fenotipo t es menor que la del resto.  9.- Los casos filadelfia positivos tienen una supervivencia menor a los hiperdiploides y los clasificados como otras alteraciones.  10.- Los pacientes que alcanzan la remisi\u00f3n completa en 4 semanas tienen una supervivencia y supervivencia libre de enfermedad superior a los que tardan m\u00e1s de 4 semanas en obtenerla.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Aportacion del estudio de los reordenamientos de las inmunoglobulinas y receptores de celulas t en el diagnostico y pronostico de la leucemia aguda linfoblastica.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Aportacion del estudio de los reordenamientos de las inmunoglobulinas y receptores de celulas t en el diagnostico y pronostico de la leucemia aguda linfoblastica. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Montserrat Lopez Rubio <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Villegas Martinez Ana M.<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Domingo Espinos Perez <\/li>\n<li>Agustin Rios Gonzales (vocal)<\/li>\n<li>Francisco Valverde Moreno (vocal)<\/li>\n<li>Julio Garcia Suarez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Montserrat Lopez Rubio Se estudia el estado de los genes de las inmunoglobulinas y receptores de c\u00e9lulas [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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