{"id":34443,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efectos-del-envejecimiento-sobre-la-funcion-vascular-en-la-rata-espontaneamente-hipertensa-consecuencias-del-bloqueo-del-sistema-renina-angiotensina\/"},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"efectos-del-envejecimiento-sobre-la-funcion-vascular-en-la-rata-espontaneamente-hipertensa-consecuencias-del-bloqueo-del-sistema-renina-angiotensina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/efectos-del-envejecimiento-sobre-la-funcion-vascular-en-la-rata-espontaneamente-hipertensa-consecuencias-del-bloqueo-del-sistema-renina-angiotensina\/","title":{"rendered":"Efectos del envejecimiento sobre la funcion vascular en la rata espontaneamente hipertensa: consecuencias del bloqueo del sistema renina-angiotensina."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Rosaura Maeso Martin <\/strong><\/h2>\n<p>Esta tesis estudia los efectos del envejecimiento sobre la funci\u00f3n vascular en la aorta aislada de ratas espontaneamente hipertensas (shr), y las consecuencias del bloqueo del sistema renina-angiotensina mediante: 1) el tratamiento antihipertensivo cr\u00f3nico de los animales con un inhibidor de la enzima de conversi\u00f3n de angiotensina, captopril, o con un antagonista de los receptores at1 de angiotensina ii (aii), losart\u00e1n, 2) la preincubaci\u00f3n de los anillos a\u00f3rticos con uno u otro f\u00e1rmaco. El envejecimiento incrementa la respuesta a vasoconstrictores con acci\u00f3n sist\u00e9mica como la aii y un agonista adren\u00e9rgico, fenilefrina, mientras que reduce la respuesta a los vasoconstrictores derivados del endotelio, y disminuye la relajaci\u00f3n dependiente e independiente de endotelio en la shr. Losart\u00e1n y captopril administrados cr\u00f3nicamente redujeron la presi\u00f3n arterial en la shr. Tanto el tratamiento antihipertensivo como la preincubaci\u00f3n de los anillos con losart\u00e1n reduce el incremento de la respuesta a aii y a fenilefr\u00edna producido por el envejecimiento. El tratamiento, as\u00ed como la preincubaci\u00f3n de los anillos con losart\u00e1n y captopril tambi\u00e9n mejor\u00f3 la empeorada relajaci\u00f3n dependiente e independiente de endotelio. De estos datos se deduce que la aii, a trav\u00e9s de los receptores at1, es responsable en gran parte de las alteraciones vasculares producidas por el envejecimiento en la shr y que la mejora inducida por el tratamiento depende principalmente de la inhibici\u00f3n de la aii, m\u00e1s que de su efecto antihipertensivo.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efectos del envejecimiento sobre la funcion vascular en la rata espontaneamente hipertensa: consecuencias del bloqueo del sistema renina-angiotensina.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efectos del envejecimiento sobre la funcion vascular en la rata espontaneamente hipertensa: consecuencias del bloqueo del sistema renina-angiotensina. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Rosaura Maeso Martin <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Vicente Lahera Julia<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda  Monica De La Fuente Del Rey <\/li>\n<li>Carlos F\u00e9lix S\u00e1nchez Ferrer (vocal)<\/li>\n<li>Enrique Aguilar Benitez De Lugo (vocal)<\/li>\n<li>Gloria Balfagon Calvo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Rosaura Maeso Martin Esta tesis estudia los efectos del envejecimiento sobre la funci\u00f3n vascular en la aorta [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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