{"id":34553,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/implicacion-del-sistema-serotoninergico-en-la-analgesia-inducida-por-calcitonina\/"},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"implicacion-del-sistema-serotoninergico-en-la-analgesia-inducida-por-calcitonina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/implicacion-del-sistema-serotoninergico-en-la-analgesia-inducida-por-calcitonina\/","title":{"rendered":"Implicacion del sistema serotoninergico en la analgesia inducida por calcitonina."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Ormazabal Lasa M. Jes\u00fas <\/strong><\/h2>\n<p>La calcitonina es una hormona polipept\u00eddica cuya principal acci\u00f3n fisiol\u00f3gica es la regulaci\u00f3n de la homeostasis del calcio. Desde que se empez\u00f3 a usar en el tratamiento de enfermedades \u00f3seas se observ\u00f3 que produc\u00eda un alivio del dolor, incluso en patolog\u00edas que no son de tipo \u00f3seo. El mecanismo por el cual la calcitonina produce analgesia no se conoce todav\u00eda. En esta tesis doctoral se estudia la implicaci\u00f3n del sistema serotonin\u00e9rgico en el efecto analg\u00e9sico de la calcitonina. Para ello se utiliza el test del \u00e1cido ac\u00e9tico como test de analgesia en el rat\u00f3n, y se miden las modificaciones de las concentraciones de serotonina, su metabolito y su precursor mediante un sistema de cromatograf\u00eda l\u00edquida de alta resoluci\u00f3n, tras distintos tratamientos farmacol\u00f3gicos.  se puede concluir de este trabajo que es necesaria la integridad del sistema serotonin\u00e9rgico para que la calcitonina pueda producir analgesia.  la analgesia inducida por la calcitonina disminuye al disminuir los niveles de 5-ht o al lesionar las v\u00edas serotonin\u00e9rgicas y aumenta cuando la actividad serotonin\u00e9rgica est\u00e1 incrementada. La activaci\u00f3n de los receptores 5-ht1a y 5ht2 reduce la analgesia de calcitonina. Se puede descartar la participaci\u00f3n de los receptores 5-ht1b\/d. El receptor 5ht3 parece fundamental en la interrelaci\u00f3n entre calcitonina y sistema serotonin\u00e9rgico, ya que su activaci\u00f3n incrementa el efecto analg\u00e9sico de la calcitonina, y su bloqueo lo disminuye.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Implicacion del sistema serotoninergico en la analgesia inducida por calcitonina.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Implicacion del sistema serotoninergico en la analgesia inducida por calcitonina. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Ormazabal Lasa M. Jes\u00fas <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda  Isabel Martin Fontelles<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Pedro Lorenzo Fernandez <\/li>\n<li>Mar\u00eda Victoria Milan\u00e9s Maquil\u00f3n (vocal)<\/li>\n<li>Juan a Benedi Gonzalez (vocal)<\/li>\n<li> Serrano Molina M. Isabel (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ormazabal Lasa M. Jes\u00fas La calcitonina es una hormona polipept\u00eddica cuya principal acci\u00f3n fisiol\u00f3gica es la regulaci\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,957],"tags":[70877,6039,8481,93134,898,10860],"class_list":["post-34553","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-farmacologia","tag-juan-a-benedi-gonzalez","tag-maria-isabel-martin-fontelles","tag-maria-victoria-milanes-maquilon","tag-ormazabal-lasa-m-jesus","tag-pedro-lorenzo-fernandez","tag-serrano-molina-m-isabel"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/34553","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=34553"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/34553\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=34553"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=34553"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=34553"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}