{"id":34557,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":""},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"deficiencia-congenita-de-cd3gamma-en-humanos-utilidad-de-sus-linfocitos-t-inmortalizados-con-herpesvirus-saimiri-para-el-estudio-del-papel-biologico-de-cd3gamma-y-una-aproximacion-a-su-terapia-genica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/deficiencia-congenita-de-cd3gamma-en-humanos-utilidad-de-sus-linfocitos-t-inmortalizados-con-herpesvirus-saimiri-para-el-estudio-del-papel-biologico-de-cd3gamma-y-una-aproximacion-a-su-terapia-genica\/","title":{"rendered":"Deficiencia congenita de cd3gamma en humanos: utilidad de sus linfocitos t inmortalizados con herpesvirus saimiri para el estudio del papel biologico de cd3gamma y una aproximacion a su terapia genica."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Alberto Pacheco Castro <\/strong><\/h2>\n<p>El papel biol\u00f3gico de cada una de las cadenas cd3 que componen el complejo tcr\/cd3 en los diferentes tipos de c\u00e9lulas no est\u00e1 aun esclarecido. Nosotros hemos inmortalizado con herpesvirus saimiri linfocitos t cd4+ de sangre perif\u00e9rica de la deficiencia humana de cd3gamma. La expresi\u00f3n del complejo tcr\/cd3 en la linea deficiente de cd3gamma inmortalizada con hvs fu\u00e9 consistentemente m\u00e1s baja (3-4 veces) en comparaci\u00f3n con los valores de la l\u00ednea control gamma+ correspondiente.  los an\u00e1lisis funcionales mostraron que la cadena cd3gamma no es imprescindible para determinadas funciones asociadas al complejo tcr\/cd3 como la movilizaci\u00f3n de calcio intracelular, inducci\u00f3n de prote\u00ednas de membrana, inducci\u00f3n de tnfalfa e ifngamma y la respuesta proliferativa. Por el contrario, la cadena cd3gamma es imprescindible para otras funciones asociadas al complejo tcr\/cd3, que se encontraban alteradas, como la modulaci\u00f3n del complejo tcr\/cd3 mediado por pma y la inducci\u00f3n de il2.  con el fin de desarrollar un modelo de terapia g\u00e9nica para la deficiencia de cd3gamma, se generaron dos vectores retrovirales que conten\u00edan cd3gamma, los cuales fueron capaces de restablecer la expresi\u00f3n y la funci\u00f3n del complejo tcr\/cd3 en un mutante de jurkat deficiente de cd3gamma. Dichos vectores podr\u00edan, por tanto, ser itilizados en ensayos de terapia g\u00e9nica.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Deficiencia congenita de cd3gamma en humanos: utilidad de sus linfocitos t inmortalizados con herpesvirus saimiri para el estudio del papel biologico de cd3gamma y una aproximacion a su terapia genica.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Deficiencia congenita de cd3gamma en humanos: utilidad de sus linfocitos t inmortalizados con herpesvirus saimiri para el estudio del papel biologico de cd3gamma y una aproximacion a su terapia genica. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Alberto Pacheco Castro <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Ramon Regueiro  Gonzalez Barros<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda  Monica De La Fuente Del Rey <\/li>\n<li>Mar\u00eda  Luisa Toribio Garcia (vocal)<\/li>\n<li> Ortiz De Candazuri Busca Manuel (vocal)<\/li>\n<li>Balbino Jos\u00e9 Alarcon Sanchez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Alberto Pacheco Castro El papel biol\u00f3gico de cada una de las cadenas cd3 que componen el complejo [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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