{"id":34608,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-del-efecto-antinociceptivo-inducido-por-los-cannabinoides-y-de-su-interaccion-con-el-sistema-opioide-central\/"},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"estudio-del-efecto-antinociceptivo-inducido-por-los-cannabinoides-y-de-su-interaccion-con-el-sistema-opioide-central","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-del-efecto-antinociceptivo-inducido-por-los-cannabinoides-y-de-su-interaccion-con-el-sistema-opioide-central\/","title":{"rendered":"Estudio del efecto antinociceptivo inducido por los cannabinoides y de su interaccion con el sistema opioide central."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ignacio Reche Ajubita <\/strong><\/h2>\n<p>Los cannabinoides son compuestos con una heterog\u00e9nea actividad farmacol\u00f3gica destacando una marcada analgesia.  sin embargo el mecanismo de acci\u00f3n por el cual estos compuestos inducen analgesia no es actualmente conocido.  la presente tesis doctoral tiene por objeto desvelar los mecanismos implicados en el efecto antinociceptivo de los cannabinnoides as\u00ed como determinar el papel del sistema opioide en este mecanismo de acci\u00f3n. Por otra parte, la interacci\u00f3n de los cannabinoides con los opi\u00e1ceos es tambi\u00e9n abordada con el objeto de establecer las bases para el desarrollo de un f\u00e1rmaco con actividad sobre ambos sistemas y con un elevado potencial como analg\u00e9sico.  como resultado del trabajo, se establece que existe un componente opioide en el mecanismo de acci\u00f3n anag\u00e9sico de los cannabinoides que implica al receptor kappa a nivel espinal. As\u00edmismo se verifica la existencia de un marcado sinergismo cuando opi\u00e1ceos y cannabinoides son administrados conjuntamente. Finalmente, la potenciaci\u00f3n analg\u00e9sica de los cannabinoides observada con la administraci\u00f3n simult\u00e1nea de opi\u00e1ceos, se reproduce cuando se coadministran con inhibidores del catabolismo de encefalinas end\u00f3genas.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio del efecto antinociceptivo inducido por los cannabinoides y de su interaccion con el sistema opioide central.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio del efecto antinociceptivo inducido por los cannabinoides y de su interaccion con el sistema opioide central. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ignacio Reche Ajubita <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda no Ruiz Gayo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Antonio Ramos Atance <\/li>\n<li>Juan a Benedi Gonzalez (vocal)<\/li>\n<li>Joaquin Del Rio Zambrana (vocal)<\/li>\n<li>Juan  Fernando Herrero  Gonzalez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ignacio Reche Ajubita Los cannabinoides son compuestos con una heterog\u00e9nea actividad farmacol\u00f3gica destacando una marcada analgesia. sin [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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