{"id":3461,"date":"1994-01-01T00:00:00","date_gmt":"1994-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1994\/01\/01\/compartimentacion-metabolica-en-el-cerebro-de-rata-adulta-detectada-por-resonancia-magnetica-nuclear-de-carbono-13\/"},"modified":"1994-01-01T00:00:00","modified_gmt":"1994-01-01T00:00:00","slug":"compartimentacion-metabolica-en-el-cerebro-de-rata-adulta-detectada-por-resonancia-magnetica-nuclear-de-carbono-13","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/compartimentacion-metabolica-en-el-cerebro-de-rata-adulta-detectada-por-resonancia-magnetica-nuclear-de-carbono-13\/","title":{"rendered":"Compartimentacion metabolica en el cerebro de rata adulta detectada por resonancia magnetica nuclear de carbono-13"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Chapa Gabriel Francisco Jose <\/strong><\/h2>\n<p>Se ha investigado la regulacion de la compartimentacion metabolica cerebral por el estado tiroideo y la selectividad para glucosa y acetato de los compartimentos neuronal y glial del cerebro adulto de rata utilizando 13c rmn. Los animales se infundieron en la yugular derecha con (i) (1,2-13c2) acetato, (ii) (2-13c, 2-2h3) acetato, o (iii) (2-13c, 2-2h3) acetato y (1-13) glucosa, y se determinaron las poblaciones de 13c-isotopomeros de glutamato, glutamina y gaba en extractos cerebrales. El analisis computerizado de las poblaciones de isotopomeros permitio determinar que la tioridectomia quirurgica: (i) disminuye el metabolismo de (1,2-13c) acetato en la glia, (ii) aumenta el metabolismo de glucosa en neuronas, y (iii) modifica significativamente los intercambios relativos de glutamato, glutamina y gaba entre neurona y glia. Durante la infusion de (2-13c,2-2h3) acetato; el 32% del glutamato glial se deriva de (2-13c, 2-2h3) acetato, el 62% de glucosa y el 6% procede de la transferencia de glutamato neuronal a la glia.  durante la infusion de (2-13c, 2-2h3) acetato, y (1-13c) glucosa; el 29% del glutamato glial se deriva del (2-13c, 2-2h3) acetato, el 12% de (1-13c) glucosa y el 60% de glucosa, mientras que el 24% del glutamato neuronal procede de (1-13c) glucosa y el 76% de glucosa. Se realizaron analisis similares de poblaciones de 13c-isotopomeros en cultivos homogeneos de neuroblastoma n2a. Estas celulas consumieron exclusivamente (1,2-13c2) glucosa y no mostraron evidencias detectables de compartimentacion metabolica, confirmando que la heterogeneidad metabolica cerebral se deriva principalmente de las diferentes poblaciones celulares.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Compartimentacion metabolica en el cerebro de rata adulta detectada por resonancia magnetica nuclear de carbono-13<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Compartimentacion metabolica en el cerebro de rata adulta detectada por resonancia magnetica nuclear de carbono-13 <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Chapa Gabriel Francisco Jose <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1994<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>esteller Cerd\u00e1n Garc\u00eda<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  Jos\u00e9 Arag\u00f3n Reyes <\/li>\n<li>Manuel Cortijo Merida (vocal)<\/li>\n<li>Gabriella Morreale  De Castro (vocal)<\/li>\n<li>Jorgina Satr\u00fastegui Gil-delgado (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Chapa Gabriel Francisco Jose Se ha investigado la regulacion de la compartimentacion metabolica cerebral por el estado [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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