{"id":34610,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/patogenia-de-la-esofagitis-por-reflujo-y-patrones-de-reflujo\/"},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"patogenia-de-la-esofagitis-por-reflujo-y-patrones-de-reflujo","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/patogenia-de-la-esofagitis-por-reflujo-y-patrones-de-reflujo\/","title":{"rendered":"Patogenia de la esofagitis por reflujo y patrones de reflujo."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Enrique Rey D\u00edaz-rubio <\/strong><\/h2>\n<p>Los objetivos de este estudio son: (1) evaluar los factores que influyen en cada etapa de progresi\u00f3n de la esofagitis por reflujo gastroesof\u00e1gico, (2) evaluar si la exposici\u00f3n esof\u00e1gica al \u00e1cido en supino y bipedestaci\u00f3n discurren de forma paralela, y si los distintos patrones de reflujo muestran mecanismos diferentes para su g\u00e9nesis. Para ello se estudiaron 143 pacientes consecutivos con s\u00edntomas t\u00edpicos de reflujo (pirosis y\/o regurgitaci\u00f3n) mediante endoscopia, manometr\u00eda y phmetr\u00eda. Se analiz\u00f3 mediante regresi\u00f3n log\u00edstica la influencia de 20 variables sobre la progresi\u00f3n de la esofagitis. Se estudiaron los patrones de reflujo mediante correlaci\u00f3n de pearson, correlaci\u00f3n parcial y an\u00e1lisis de la varianza. Las variables independientes asociadas a la progresi\u00f3n de las lesiones esof\u00e1gicas fueron: (1) desarrollo de esofagitis no erosiva: edad e \u00edndice de reflujo en supino, (2) desarrollo de esofagitis erosiva: trastorno motor esof\u00e1gico significativo y exposici\u00f3n al \u00e1cido en bipedestaci\u00f3n, (3) desarrollo de es\u00f3fago de barrett: presi\u00f3n del esf\u00ednter esof\u00e1gico inferior y exposici\u00f3n total al \u00e1cido. Aunque el porcentaje de tiempo con ph menor a 4 en bipedestaci\u00f3n y en supino se correlacionan, \u00e9sta desaparece al corregir por el porcentaje de tiempo postprandial, confirm\u00e1ndose en un subgrupo de 34 pacientes en los que los periodos postprandial y supino no se solapaban. Se encontraron diferencias significativas en el \u00edndice de reflujo y el aclaramiento esof\u00e1gico en supino, y en el \u00edndice de reflujo en bipedestaci\u00f3n al comparar los distintos patrones. En conclusi\u00f3n, este estudio apunta (1) que el aumento del n\u00famero de episodios de reflujo en supino ser\u00eda decisivo para el desarrollo de esofagitis no erosiva y el aumento de la exposici\u00f3n al \u00e1cido en bipedestaci\u00f3n y la presencia de un trastorno motor esof\u00e1gico inducir\u00edan el desarrollo de esofagitis erosiva, y (2) apoya la existencia de diferentes pa<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Patogenia de la esofagitis por reflujo y patrones de reflujo.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Patogenia de la esofagitis por reflujo y patrones de reflujo. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Enrique Rey D\u00edaz-rubio <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Manuel Diaz Rubio Garcia<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Domingo Espinos Perez <\/li>\n<li> Pajares Garc\u00eda Jos\u00e9 Mar\u00eda (vocal)<\/li>\n<li>Julio De La Morena Fern\u00e1ndez (vocal)<\/li>\n<li> Herrerias Gutierrez Juan  Manuel (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Enrique Rey D\u00edaz-rubio Los objetivos de este estudio son: (1) evaluar los factores que influyen en cada 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