{"id":34657,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/alteraciones-de-p53-rb-e-inhibidores-de-quinass-dependientes-de-ciclinas-en-linfomas-estudio-inmunofenotipico-y-genotipico\/"},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"alteraciones-de-p53-rb-e-inhibidores-de-quinass-dependientes-de-ciclinas-en-linfomas-estudio-inmunofenotipico-y-genotipico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/alteraciones-de-p53-rb-e-inhibidores-de-quinass-dependientes-de-ciclinas-en-linfomas-estudio-inmunofenotipico-y-genotipico\/","title":{"rendered":"Alteraciones de p53, rb e inhibidores de quinass dependientes de ciclinas en linfomas: estudio inmunofenotipico y genotipico."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Margarita Sanchez-beato Gomez <\/strong><\/h2>\n<p>En esta tesis doctoral se plantea la hip\u00f3tesis de que alteraciones en la regulaci\u00f3n de la fase g1 del ciclo celular ejercida por p53, rb y los cdkis p21, p27 y p16, podr\u00eda participar en linfomag\u00e9nesis. Se pretende establecer la existencia de alteraciones en los genes o\/y prote\u00ednas de los cdkis, as\u00ed como determinar cuales son las m\u00e1s frecuentes y su relaci\u00f3n con la transformaci\u00f3n agresiva de los linfomas. Las conclusiones m\u00e1s importantes son:  la expresi\u00f3n de p21 y mdm2 en lnh depende de mutaciones en p53. Estas prote\u00ednas se expresan en eh, por lo que p53 se supone transcripcionalmente activa.- La expresi\u00f3n de p27 es inversamente proporcional a la proliferaci\u00f3n en linfomas. Existe un grupo de lnh de alto grado con expresi\u00f3n an\u00f3mala de p27; se caracterizan por la inactivaci\u00f3n de p53.- La existencia de anomal\u00edas en p16 es cr\u00edtica en lnh, siendo una alteraci\u00f3n frecuente en alto grado y muy frecuente en transformaci\u00f3n agresiva. La ausencia de expresi\u00f3n se debe preferentemente a metilaci\u00f3n del promotor o p\u00e9rdida al\u00e9lica. Existen alteraciones en la expresi\u00f3n de rb en casos de eh que, posteriormente, han demostrado ser cl\u00ednicamente relevantes.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Alteraciones de p53, rb e inhibidores de quinass dependientes de ciclinas en linfomas: estudio inmunofenotipico y genotipico.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Alteraciones de p53, rb e inhibidores de quinass dependientes de ciclinas en linfomas: estudio inmunofenotipico y genotipico. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Margarita Sanchez-beato Gomez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Miguel Angel Piris Pinilla<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda  Antonia Lizarbe  Iracheta <\/li>\n<li>Manuel Serrano (vocal)<\/li>\n<li>Augusto Silva Gonzalez (vocal)<\/li>\n<li>Elias Campo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Margarita Sanchez-beato Gomez En esta tesis doctoral se plantea la hip\u00f3tesis de que alteraciones en la regulaci\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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