{"id":34687,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-circadiano-de-los-efectos-de-la-ciclosporina-a-sobre-el-tejido-linfoide-y-su-posible-modulacion-por-la-inervacion-simpatica-local\/"},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"estudio-circadiano-de-los-efectos-de-la-ciclosporina-a-sobre-el-tejido-linfoide-y-su-posible-modulacion-por-la-inervacion-simpatica-local","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/estudio-circadiano-de-los-efectos-de-la-ciclosporina-a-sobre-el-tejido-linfoide-y-su-posible-modulacion-por-la-inervacion-simpatica-local\/","title":{"rendered":"Estudio circadiano de los efectos de la ciclosporina a sobre el tejido linfoide y su posible modulacion por la inervacion simpatica local."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Laura Selgas Lopez <\/strong><\/h2>\n<p>Existen variaciones circadianas en la funci\u00f3n inmunitaria de la rata macho adulta de la cepa wistar cuyas acrofases var\u00edan en funci\u00f3n del tejido y par\u00e1metro inmunitario analizado, como consecuencia de una regulaci\u00f3n nerviosa de la propia funci\u00f3n inmunitaria. La administraci\u00f3n de ciclosporina a, f\u00e1rmaco inmunosupresor utilizado en cl\u00ednica para prevenir el rechazo en el trasplante de \u00f3rganos, en diferentes momentos del ciclo circadiano induce un efecto tiempo de administraci\u00f3n dependiente sobre la proliferaci\u00f3n linfocitaria siendo la mayor respuesta inmunosupresora durante el per\u00edodo de descanso de los animales, que adem\u00e1s coincide con un incremento de la actividad simp\u00e1tica. La denervaci\u00f3n simp\u00e1tica de los ganglios linf\u00e1ticos submaxilares, mediante una ganglionectom\u00eda cervical unilateral, no consigue alterar el patr\u00f3n circadiano de respuesta proliferativa linfocitaria, sin embargo, potencia el efecto inmunosupresor del f\u00e1rmaco.  los resultados obtenidos sugieren que, al menos en parte, los efectos de la ciclosporina a sobre el tejido linfoide est\u00e1n mediados por cambios en la actividad simp\u00e1tica en este tejido.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio circadiano de los efectos de la ciclosporina a sobre el tejido linfoide y su posible modulacion por la inervacion simpatica local.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio circadiano de los efectos de la ciclosporina a sobre el tejido linfoide y su posible modulacion por la inervacion simpatica local. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Laura Selgas Lopez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ana Isabel Esquifino Parras<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Manuel Ruiz Amil <\/li>\n<li>Ascension Marcos Sanchez (vocal)<\/li>\n<li>Pablo Gil Loyzaga (vocal)<\/li>\n<li>Mar\u00eda Anunciaci\u00f3n Lafuente Gim\u00e9nez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Laura Selgas Lopez Existen variaciones circadianas en la funci\u00f3n inmunitaria de la rata macho adulta de la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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