{"id":34737,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/bases-moleculares-de-la-regulacion-transcripcional-de-la-oxido-nitrico-sintasa-inducible-en-el-hepatocito\/"},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"bases-moleculares-de-la-regulacion-transcripcional-de-la-oxido-nitrico-sintasa-inducible-en-el-hepatocito","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/bases-moleculares-de-la-regulacion-transcripcional-de-la-oxido-nitrico-sintasa-inducible-en-el-hepatocito\/","title":{"rendered":"Bases moleculares de la regulacion transcripcional de la oxido nitrico sintasa inducible en el hepatocito."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Marta Velasco Cardenal <\/strong><\/h2>\n<p>El \u00f3xido n\u00edtrico (no) es un segundo mensajero clave en la se\u00f1alizaci\u00f3n de diversos procesos fisiol\u00f3gicos. Sin embargo, una producci\u00f3n excesiva y desregulada de este radical puede causar da\u00f1o tisular. El no es sintetizado a partir de l-arginina por la \u00f3xido n\u00edtrico sintasa. En mam\u00edferos, se han identificado tres isoformas diferentes de esta enzima, dos de ellas constitutivas y una inducible. La \u00f3xido n\u00edtrico sintasa inducible (inos) es expresada en una gran variedad de tipos celulares en respuesta a diferentes est\u00edmulos inmunes e inflamatorios.  numerosos trabajos han implicado al no y a la inos en la fisiopatolog\u00eda hep\u00e1tica. Ya que la expresi\u00f3n de inos es regulada principalmente a nivel transcripcional, el estudio realizado trata de establecer los mecanismos moleculares que controlan su expresi\u00f3n. Los resultados mostrados en este trabajo permiten concluir que procesos infeccioso-inflamatorios conducen a la expresi\u00f3n de inos en el h\u00edgado tras la activaci\u00f3n transitoria de diferentes factores de transcripci\u00f3n tales como nf-kb; ap-1, irf y gas, siendo nf-kb el elemento esencial de esta inducci\u00f3n.  dado el importante papel que juega nf-kb se ha estudiado tambi\u00e9n el mecanismo que regula la activaci\u00f3n de este factor de transcripci\u00f3n.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Bases moleculares de la regulacion transcripcional de la oxido nitrico sintasa inducible en el hepatocito.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Bases moleculares de la regulacion transcripcional de la oxido nitrico sintasa inducible en el hepatocito. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Marta Velasco Cardenal <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Lisardo Bosc\u00e1 Gomar<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Evangelina Palacios Alaiz <\/li>\n<li>Paloma Martin Sanz (vocal)<\/li>\n<li>Santiago Lamas Pel\u00e1ez (vocal)<\/li>\n<li>Ramon Bartrons Bach (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Marta Velasco Cardenal El \u00f3xido n\u00edtrico (no) es un segundo mensajero clave en la se\u00f1alizaci\u00f3n de diversos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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