{"id":3478,"date":"1994-01-01T00:00:00","date_gmt":"1994-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1994\/01\/01\/caracteristicas-proliferativas-de-las-celulas-tumorales-asciticas-de-ehrlich\/"},"modified":"1994-01-01T00:00:00","modified_gmt":"1994-01-01T00:00:00","slug":"caracteristicas-proliferativas-de-las-celulas-tumorales-asciticas-de-ehrlich","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/caracteristicas-proliferativas-de-las-celulas-tumorales-asciticas-de-ehrlich\/","title":{"rendered":"Caracteristicas proliferativas de las celulas tumorales asciticas de ehrlich"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ana Elexpuru Artetxe <\/strong><\/h2>\n<p>Hemos observado que las celulas tumorales asciticas de ehrlich presentan altos niveles de sintesis de dna en cultivo, independiente de factores de crecimiento exogenos. Hemos demostrado que estas celulas secretan tgf 1 al medio de cultivo aunque no presentan receptores detectables para este factor. Utilizando un extracto etanol\/acido de estas celulas hemos observado que provoca in vitro la fosforilacion de una proteina de 98 kda presente en todas las lineas ensayadas (mv1lu, ehrlich, swiss 3t3, egfr t17 y nrk). Esta fosforilacion se produce en residuos de serina y treonina de una manera dependiente de la concentracion. Hemos observado que el egf induce una ligera disminucion de la proliferacion de las celulas tumorales de ehrlich, a pesar de que el receptor para este factor parece estar spbreexpresado expresado en esta linea. Hemos calculado la presencia de 320.000 receptores por celula distribuidos en dos poblaciones de alta y de baja afinidad para el egf. Hemos observado que a pesar del alto numero de receptores, los niveles de autofosforilacion no son tan altos como cabria esperar. Utilizando un anticuerpo policlonal contra el receptor del egf hemos inmunoprecipitado una proteina de 45 kda presente en las celulas de ehrlich, que se fosforila in vitro en residuos de serina independientemente del egf.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracteristicas proliferativas de las celulas tumorales asciticas de ehrlich<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracteristicas proliferativas de las celulas tumorales asciticas de ehrlich <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ana Elexpuru Artetxe <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1994<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Villalobo Polo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda  Monica De La Fuente Del Rey <\/li>\n<li>Abelardo L\u00f3pez Rivas (vocal)<\/li>\n<li>Miguel Quintanilla Avila (vocal)<\/li>\n<li>Mar\u00eda  Isabel Fabregat Romero (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ana Elexpuru Artetxe Hemos observado que las celulas tumorales asciticas de ehrlich presentan altos niveles de sintesis [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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