{"id":34800,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":""},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"contribucion-al-conocimiento-patobiologico-del-cancer-colo-rectal-estudio-analitico-comparativo-de-la-expresion-inmunohistoquimica-de-la-proteina-p53-ploidia-de-adn-y-otros-parametros-clinicopatolog","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/contribucion-al-conocimiento-patobiologico-del-cancer-colo-rectal-estudio-analitico-comparativo-de-la-expresion-inmunohistoquimica-de-la-proteina-p53-ploidia-de-adn-y-otros-parametros-clinicopatolog\/","title":{"rendered":"Contribucion al conocimiento patobiologico del cancer colo-rectal: estudio analitico comparativo de la expresion inmunohistoquimica de la proteina p53, ploidia de adn y otros parametros clinicopatologicos."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Garcia Hirschfeld Garcia Juan  M. <\/strong><\/h2>\n<p>El carcinoma colo-rectal (ccr) es un problema sanitario de primer orden. Constituye la neoplasia m\u00e1s frecuente del aparato digestivo, y la segunda causa de muerte por c\u00e1ncer en europa y norteam\u00e9rica.  el estudio de los cambios gen\u00e9ticos y moleculares desarrollados en el proceso de la carcinog\u00e9nesis colo-rectal est\u00e1 contribuyendo a identificar diferentes grupos de riesgo de padecer esta neoplasia, as\u00ed como a profundizar en el concepto patog\u00e9nico de la secuencia adenoma-carcinoma.  el ccr es una enfermedad muy heterog\u00e9nea en cuanto a su evoluci\u00f3n biol\u00f3gica y, por tanto, en cuanto a su pron\u00f3stico, incluso estadio por estadio. Adem\u00e1s, es desalentador para el pat\u00f3logo observar la \u00abmonoton\u00eda\u00bb histol\u00f3gica del adenocarcinoma colo-rectal, normalmente muy similar de un caso a otro.  ante este planteamiento, se hace necesario buscar otros par\u00e1metros complementarios a los morfol\u00f3gicos convencionales, que aporten, de alg\u00fan modo, informaci\u00f3n adicional acerca de la biolog\u00eda tumoral.  en el caso del ccr, una de las alteraciones gen\u00e9ticas m\u00e1s frecuente se observa a nivel de la p53 (proteina que parece intervenir en la progresi\u00f3n de adenoma \u00abtardio\u00bb a carcinoma), si bien es la acumulaci\u00f3n de cambios gen\u00e9ticos, m\u00e1s que el orden cronol\u00f3gico en que se sucedan, la que determinar\u00e1 evoluci\u00f3n biol\u00f3gica de la neoplasia.  a la vista de estas consideraciones, en el presente estudio se pretende:  1. Determinar la expresi\u00f3n inmunohistoqu\u00edmica de la prote\u00edna p53 en nuestra serie de 65 ccr.  2. Establecer un estudio anal\u00edtico de correlaci\u00f3n entre variables clinicopatol\u00f3gicas, citom\u00e9tricas (ploid\u00eda de adn, fase s, \u00edndice de proliferaci\u00f3n) y dicha expresi\u00f3n de p53.  3. Determinar, por otro lado, la expresi\u00f3n inmunohistoqu\u00edmica de la prote\u00edna p53 en la serie de 28 p\u00f3lipos adenomatosos, sincr\u00f3nicos con algunos de los ccr de la serie estudiada. Asimismo, se pretende correlacionar dicha expresi\u00f3n con los par\u00e1<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Contribucion al conocimiento patobiologico del cancer colo-rectal: estudio analitico comparativo de la expresion inmunohistoquimica de la proteina p53, ploidia de adn y otros parametros clinicopatologicos.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Contribucion al conocimiento patobiologico del cancer colo-rectal: estudio analitico comparativo de la expresion inmunohistoquimica de la proteina p53, ploidia de adn y otros parametros clinicopatologicos. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Garcia Hirschfeld Garcia Juan  M. <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 M\u00e1laga<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Alfredo Matilla Vicente<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Fuente Perucho Agust\u00edn De La <\/li>\n<li>Juan  Jos\u00e9 Sanchez Carrillo (vocal)<\/li>\n<li>Francisco Rivera Hueto (vocal)<\/li>\n<li>Antonio L\u00f3pez Beltr\u00e1n (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Garcia Hirschfeld Garcia Juan M. El carcinoma colo-rectal (ccr) es un problema sanitario de primer orden. Constituye [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[8901,9,7834,1027,156],"tags":[7890,7892,10967,8210,93534,26540],"class_list":["post-34800","post","type-post","status-publish","format-standard","hentry","category-carcinogenesis","category-ciencias-medicas","category-malaga","category-oncologia","category-patologia","tag-alfredo-matilla-vicente","tag-antonio-lopez-beltran","tag-francisco-rivera-hueto","tag-fuente-perucho-agustin-de-la","tag-garcia-hirschfeld-garcia-juan-m","tag-juan-jose-sanchez-carrillo"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/34800","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=34800"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/34800\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=34800"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=34800"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=34800"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}