{"id":34851,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-del-efecto-antioxidante-de-propofol-en-tejidos-normales-y-en-un-modelo-de-anoxia-hiperoxia-cerebral-en-la-rata\/"},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"estudio-del-efecto-antioxidante-de-propofol-en-tejidos-normales-y-en-un-modelo-de-anoxia-hiperoxia-cerebral-en-la-rata","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-del-efecto-antioxidante-de-propofol-en-tejidos-normales-y-en-un-modelo-de-anoxia-hiperoxia-cerebral-en-la-rata\/","title":{"rendered":"Estudio del efecto antioxidante de propofol en tejidos normales y en un modelo de anoxia\/hiperoxia cerebral en la rata."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Guadalupe Sede\u00f1o Martin <\/strong><\/h2>\n<p>El objetivo del trabajo es comprobar y cuantificar el posible efecto que el anestesico general intravenoso propofol presenta sobre algun aspecto del estatus oxidativo tisular en la rata. Se realizaron dos tipos de experiencias: estudios in vitro en tejidos normales y estudios in vitro en tejido cerebral sometido a diversos periodos de anoxia y reoxigenaci\u00f3n propofol mostro un efecto inhibidor de la peroxidaci\u00f3n lipidica de forma concentraci\u00f3n-dependiente en todos los tejidos estudiados y en un rango 1-50 micromolar. En tejidos normales produce un acumulo de glutati\u00f3n reducido, fundamental para preparar un tejido ante una agresi\u00f3n oxidativa. En el modelo de anoxia\/hiperoxia cerebral, el tejido cerebral sufre un incremento muy ostensible del da\u00f1o oxidativo y una disminuci\u00f3n de las defensas antioxidantes, lesiones bioquimicas que propofol revierte de forma concentraci\u00f3n-dependiente. Conclusion: propofol pueden considerarse como un buen farmaco antioxidante en el rango de concentraciones que se utilizan en clinica humana.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio del efecto antioxidante de propofol en tejidos normales y en un modelo de anoxia\/hiperoxia cerebral en la rata.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio del efecto antioxidante de propofol en tejidos normales y en un modelo de anoxia\/hiperoxia cerebral en la rata. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Guadalupe Sede\u00f1o Martin <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 M\u00e1laga<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Pedro De La Cruz Cort\u00e9s<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francisco Lopez Timoneda <\/li>\n<li>Antonio Moreno Guerrero (vocal)<\/li>\n<li>Raimundo Carlos Garcia (vocal)<\/li>\n<li> Carmona Aurioles Jos\u00e9 Antonio (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Guadalupe Sede\u00f1o Martin El objetivo del trabajo es comprobar y cuantificar el posible efecto que el anestesico [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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