{"id":34911,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/deteccion-y-cuantificacion-de-aztreonam-en-suero-y-tejido-prostatico-y-vesical-por-hplc-administracion-via-intravenosa-vs-submucosa-anal\/"},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"deteccion-y-cuantificacion-de-aztreonam-en-suero-y-tejido-prostatico-y-vesical-por-hplc-administracion-via-intravenosa-vs-submucosa-anal","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/deteccion-y-cuantificacion-de-aztreonam-en-suero-y-tejido-prostatico-y-vesical-por-hplc-administracion-via-intravenosa-vs-submucosa-anal\/","title":{"rendered":"Deteccion y cuantificacion de aztreonam en suero y tejido prostatico y vesical por hplc. administracion via intravenosa vs submucosa anal."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Gregorio Hita Villaplana <\/strong><\/h2>\n<p>Los estudios sobre la patolog\u00eda infecciosa prost\u00e1tica, debido a su alta frecuencia son de rentabilidad m\u00e9dica y econ\u00f3mica. El n\u00famero de fracasos terap\u00e9uticos es importante por lo que probablemente existen factores desconocidos que determinan la eficacia de los antibi\u00f3ticos.  por tanto, se propone desarrollar un estudio con los siguientes objetivos:  &#8211; estandarizar un m\u00e9todo cromatogr\u00e1fico eficaz para la detecci\u00f3n, separaci\u00f3n y cuantificaci\u00f3n de aztreonam en suero y tejidos.  &#8211; investigar la capacidad de este antibi\u00f3tico para alcanzar concentraciones terap\u00e9uticas en tejido prost\u00e1tico y vejiga, este \u00faltimo con la finalidad de cuantificar concentraciones en un \u00f3rgano diferente de la pr\u00f3stata.  &#8211; estudiar la relaci\u00f3n existente entre la v\u00eda de administraci\u00f3n y penetraci\u00f3n de aztreonam a pr\u00f3stata y vejiga. Para ello se compararon dos v\u00edas de administraci\u00f3n la v\u00eda intravenosa y la submucosa anal.  se ha puesto a punto un m\u00e9todo anal\u00edtico mediante hplc para la determinaci\u00f3n de aztreonam, con una especificidad, sensibilidad y reproducibilidad adecuadas para la cuantificaci\u00f3n del f\u00e1rmaco en suero y tejido prost\u00e1tico. Los estudios realizados con cefazolina permiten concluir que se puede utilizar como patr\u00f3n interno \u00f3ptimo para la cuantificaci\u00f3n de aztreonam.  se estudiaron 18 pacientes que deb\u00edan de ser sometidos a rtu de pr\u00f3stata los cuales eran previamente inyectados con aztreonam por las dos v\u00edas estudiadas. En estos se determinaron concentraciones en suero, tejido vesical y diferentes zonas de adenoma prost\u00e1tico.  los valores de aztreonam obtenidos en suero de pacientes tratados por v\u00eda submucosa anal (44.58 microg\/ml) son similares a los objetivos tras la inyecci\u00f3n intravenosa (58.86 microg\/ml), lo que indica que aquella v\u00eda no es espec\u00edfica para la llegada de f\u00e1rmacos a \u00f3rganos abdominales.  las concentraciones de aztreonam en pr\u00f3stata fueron siempre superiores a la mic90 para mu<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Deteccion y cuantificacion de aztreonam en suero y tejido prostatico y vesical por hplc. administracion via intravenosa vs submucosa anal.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Deteccion y cuantificacion de aztreonam en suero y tejido prostatico y vesical por hplc. administracion via intravenosa vs submucosa anal. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Gregorio Hita Villaplana <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Murcia<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda Victoria Milan\u00e9s Maquil\u00f3n<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Roque Jos\u00e9 (secretario) Ortiz Gonzalez <\/li>\n<li>Mar\u00eda Luisa Laorden Carrasco (vocal)<\/li>\n<li>Damian Garc\u00eda Olmo (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Gregorio Hita Villaplana Los estudios sobre la patolog\u00eda infecciosa prost\u00e1tica, debido a su alta frecuencia son de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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