{"id":34931,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-molecular-de-la-resistencia-a-quinolonas-en-100-aislamientos-clinicos-de-staphylococcus-aureus-mediante-el-analisis-del-polimorfismo-estructural-de-las-cadenas-sencillas-sscp\/"},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"caracterizacion-molecular-de-la-resistencia-a-quinolonas-en-100-aislamientos-clinicos-de-staphylococcus-aureus-mediante-el-analisis-del-polimorfismo-estructural-de-las-cadenas-sencillas-sscp","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/caracterizacion-molecular-de-la-resistencia-a-quinolonas-en-100-aislamientos-clinicos-de-staphylococcus-aureus-mediante-el-analisis-del-polimorfismo-estructural-de-las-cadenas-sencillas-sscp\/","title":{"rendered":"Caracterizacion molecular de la resistencia a quinolonas en 100 aislamientos clinicos de staphylococcus aureus mediante el analisis del polimorfismo estructural de las cadenas sencillas (sscp)."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Juan  Andres Martinez Andres <\/strong><\/h2>\n<p>Las infecciones por staphylococcus aureus suponen en la actualidad un grave problema sanitario, siendo las quinolonas en muchas ocasiones la alternativa m\u00e1s adecuada en el tratamiento de las mismas, aunque la resistencia a quinolonas afecta en la actualidad a un gran n\u00famero de clones. Con dicha resistencia se han relacionado mutaciones que afectan a diversos genes, y que ocurren en regiones bien delimitadas de los mismos, lo que hace accesible su estudio mediante la t\u00e9cnica de sscp. Se determin\u00f3 la actividad de diversas quinolonas frente a 100 cepas de s. Aureus procedentes de aislamientos cl\u00ednicos y se caracterizaron los mecanismos de resistencia a quinolonas presentes en dichas cepas.  las mol\u00e9culas m\u00e1s activas fueron pd 138312 y pd 140248 cuyos valores de cmi50 y cmi90 resultaron 64 veces inferiores a los obtenidos con ciprofloxacino, si bien las mol\u00e9culas ensayadas se vieron afectadas por la adquisici\u00f3n de resistencia a quinolonas por s. Aureus de forma general. La alteraci\u00f3n m\u00e1s frecuente en gyra fue la de serina-84 por leucina (que confiri\u00f3 resistencia de alto nivel) y la m\u00e1s frecuente en grla la de serina-80 por fenilalanina (que confiri\u00f3 resistencia moderada). No se detectaron cambios en gyrb. La diana primaria de las quinolonas fue la topoisomerasa iv, ya que en ella se detectaron alteraciones de forma aislada, mientras que todas las sustituciones de ser-84 por leu en gyra se acompa\u00f1aron de cambios en grla. Se detectaron cuatro variantes en el promotor de nora con distintos niveles de expresi\u00f3n, cuya contribuci\u00f3n a la resistencia qued\u00f3 condicionada por el fenotipo de las topoisomerasas.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizacion molecular de la resistencia a quinolonas en 100 aislamientos clinicos de staphylococcus aureus mediante el analisis del polimorfismo estructural de las cadenas sencillas (sscp).<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizacion molecular de la resistencia a quinolonas en 100 aislamientos clinicos de staphylococcus aureus mediante el analisis del polimorfismo estructural de las cadenas sencillas (sscp). <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Juan  Andres Martinez Andres <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Murcia<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Manuel Segovia Hern\u00e1ndez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  Jos\u00e9 Picazo De La Garza <\/li>\n<li>Jes\u00fas Mart\u00ednez Beltr\u00e1n (vocal)<\/li>\n<li>Mar\u00eda no Gacto Fern\u00e1ndez (vocal)<\/li>\n<li>Juan  Luis Mu\u00f1oz Bellido (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Juan Andres Martinez Andres Las infecciones por staphylococcus aureus suponen en la actualidad un grave problema sanitario, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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