{"id":34956,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/interaccion-cardiovascular-angiotensina-ii-peptido-natriuretico-en-la-hipertension-arterial-experimental\/"},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"interaccion-cardiovascular-angiotensina-ii-peptido-natriuretico-en-la-hipertension-arterial-experimental","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/interaccion-cardiovascular-angiotensina-ii-peptido-natriuretico-en-la-hipertension-arterial-experimental\/","title":{"rendered":"Interaccion cardiovascular angiotensina ii-peptido natriuretico en la hipertension arterial experimental."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Antonio  Jose Ortiz Ruiz <\/strong><\/h2>\n<p>El objetivo de esta tesis doctoral ha sido estudiar los efectos cardiovasculares de los antagonistas de los receptores de la angiotensina ii (aii), saralasina y losart\u00e1n, en la hipertensi\u00f3n vasculorrenal 2 ri\u00f1ones-1 clip (2r-1c) y en la hipertensi\u00f3n l-name por d\u00e9ficit cr\u00f3nico de \u00f3xido n\u00edtrico (no). Adem\u00e1s, hemos determinado los efectos cardiovasculares del p\u00e9ptido natriur\u00e9tico auricular (pna) y su modulaci\u00f3n por el tratamiento agudo o cr\u00f3nico con los bloqueantes antes mencionados. Los principales resultados han sido: 1. La hipertensi\u00f3n 2r-1c en su fase aguda cursa con niveles elevados de presi\u00f3n arterial (pa) y ligeros cambios del \u00edndice card\u00edaco (ic) y de las resistencias perif\u00e9ricas (rpt). 2. La hipertensi\u00f3n name, de similar duraci\u00f3n, se caracteriza por un ic muy bajo y unas rpt muy elevadas, a\u00fan mostrando una pa similar. 3. El tratamiento agudo con losart\u00e1n disminuye la pa en ambos modelos, a expensas de la disminuci\u00f3n de las rpt. 4. El tratamiento agudo con saralasina disminuye la pa s\u00f3lo en el modelo de hipertensi\u00f3n 2r-1c, tambi\u00e9n a expensas de la disminuci\u00f3n de las rpt. 5. El tratamiento cr\u00f3nico con losart\u00e1n previene el desarrollo de la hipertensi\u00f3n 2r-1c, aunque sin normalizar completamente las rpt. 6. El tratamiento cr\u00f3nico con losart\u00e1n previene el desarrollo de la hipertensi\u00f3n name, aunque sin normalizar completamente las rpt y el 1c. 7. Al contrario que el losart\u00e1n, la saralasina no disminuye la pa en animales controles y \u00e9sto es debido al aumento del ic, ya que ambas drogas disminuyen por igual las rpt. Estos efectos, sin embargo, son de peque\u00f1a magnitud. 8. La administraci\u00f3n de saralasina a animales con hipertensi\u00f3n 2r-1c permite diferenciar dos grupos, sensibles y resistentes, seg\u00fan su mayor o menor respuesta hipotensora, respectivamente, a la saralasina. Por el contrario, la respuesta hipotensora al losart\u00e1n en la hipertensi\u00f3n 2r-1c es homog\u00e9nea. 9. En todos los grupos experim<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Interaccion cardiovascular angiotensina ii-peptido natriuretico en la hipertension arterial experimental.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Interaccion cardiovascular angiotensina ii-peptido natriuretico en la hipertension arterial experimental. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Antonio  Jose Ortiz Ruiz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Murcia<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Garcia Esta\u00f1 Lopez Joaquin<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Luis Fernando Carbonell Meseguer <\/li>\n<li>Jes\u00fas Hernandez Cascales (vocal)<\/li>\n<li>Jos\u00e9 F\u00e9lix Vargas Palomares (vocal)<\/li>\n<li>Manuel Diez Miralles (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Antonio Jose Ortiz Ruiz El objetivo de esta tesis doctoral ha sido estudiar los efectos cardiovasculares de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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