{"id":34957,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/alteraciones-de-la-funcion-renal-en-la-cirrosis-hepatica-experimental-papel-del-oxido-nitrico\/"},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"alteraciones-de-la-funcion-renal-en-la-cirrosis-hepatica-experimental-papel-del-oxido-nitrico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/alteraciones-de-la-funcion-renal-en-la-cirrosis-hepatica-experimental-papel-del-oxido-nitrico\/","title":{"rendered":"Alteraciones de la funcion renal en la cirrosis hepatica experimental: papel del oxido nitrico."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda  Clara Ortiz Ruiz <\/strong><\/h2>\n<p>En esta tesis doctoral hemos valorado el papel del no en dos modelos de cirrosis experimental, el de inhalaci\u00f3n cr\u00f3nica de tetracloruro de carbono y el de ligadura del conducto biliar. Los principales resultados y conclusiones son. 1) la hiporrespuesta vascular sist\u00e9mica a vasoconstrictores es debida a una mayor producci\u00f3n de \u00f3xido n\u00edtrico constitutivo de origen endotelial. 2) el mantenimiento de la respuesta vasodilatadora dependiente de endotelio sugiere que no todos los mecanismos de liberaci\u00f3n de \u00f3xido n\u00edtrico est\u00e1n alterados en el modelo de ligadura cr\u00f3nica del conducto biliar. 3) el ri\u00f1\u00f3n cirr\u00f3tico muestra una menor capacidad vasodilatadora intrarrenal global, debida a la disminuci\u00f3n del componente dependiente de prostaglandinas que no es compensado por la mayor producci\u00f3n de \u00f3xido n\u00edtrico. 4) los efectos beneficiosos sobre presi\u00f3n arterial y excreci\u00f3n de agua y sodio de la aminoguanidina sugieren la participaci\u00f3n de la isoforma inducible de la sintasa de \u00f3xido n\u00edtrico en las alteraciones sist\u00e9micas y renales de los animales con cirrosis por cl4c y por ligadura del conducto biliar. 5) la falta de normalizaci\u00f3n de los par\u00e1metros estudiados tras la administraci\u00f3n de aminoguanidina indica la presencia de otros mecanismos, dependientes de \u00f3xido n\u00edtrico de origen constitutivo, que tambi\u00e9n contribuyen a la hipotensi\u00f3n y retenci\u00f3n de sodio de los animales con cirrosis experimental. 6) la administraci\u00f3n de aminoguanidina no es una buena elecci\u00f3n para el tratamiento a largo plazo de la hipotensi\u00f3n arterial y retenci\u00f3n de sodio de los animales cirr\u00f3ticos con ascitis. Por el contrario, el efecto beneficioso cr\u00f3nico se consigue con el inhibidor inespec\u00edfico de la s\u00edntesis de \u00f3xido n\u00edtrico, l-name. 7) las alteraciones morfol\u00f3gicas del ri\u00f1\u00f3n de ratas con ligadura del conducto biliar detectadas con el sistema de esc\u00e1ner microcomputerizado, son compatibles con la retenci\u00f3n de sodio y sugieren la<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Alteraciones de la funcion renal en la cirrosis hepatica experimental: papel del oxido nitrico.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Alteraciones de la funcion renal en la cirrosis hepatica experimental: papel del oxido nitrico. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda  Clara Ortiz Ruiz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Murcia<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Joaquin Garcia Esta\u00f1<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Tomas Quesada Perez <\/li>\n<li>Vicente Arroyo Perez (vocal)<\/li>\n<li>Carlos Romero J. (vocal)<\/li>\n<li> Lozano Teruel J. Antonio (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Clara Ortiz Ruiz En esta tesis doctoral hemos valorado el papel del no en dos modelos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[35,9,817,139,8235,179],"tags":[93784,35513,93785,93783,24894,19655],"class_list":["post-34957","post","type-post","status-publish","format-standard","hentry","category-ciencias-de-la-vida","category-ciencias-medicas","category-fisiologia-humana","category-medicina-interna","category-murcia","category-nefrologia","tag-carlos-romero-j","tag-joaquin-garcia-estan","tag-lozano-teruel-j-antonio","tag-maria-clara-ortiz-ruiz","tag-tomas-quesada-perez","tag-vicente-arroyo-perez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/34957","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=34957"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/34957\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=34957"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=34957"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=34957"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}