{"id":34982,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efectos-de-los-peptidos-trh-likepglu-glu-pro-amida-y-pglu-phe-pro-amida-sobre-la-conducta-motora-de-la-rata\/"},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"efectos-de-los-peptidos-trh-likepglu-glu-pro-amida-y-pglu-phe-pro-amida-sobre-la-conducta-motora-de-la-rata","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/efectos-de-los-peptidos-trh-likepglu-glu-pro-amida-y-pglu-phe-pro-amida-sobre-la-conducta-motora-de-la-rata\/","title":{"rendered":"Efectos de los peptidos trh-like,pglu-glu-pro amida y pglu-phe-pro amida. sobre la conducta motora de la rata."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Rosa Mar\u00eda Sanchez Alonso <\/strong><\/h2>\n<p>Recientemente se ha descrito la existencia de tres an\u00e1logos naturales de la trh en pr\u00f3stata y semen. Estos p\u00e9ptidos trh-like se diferencian de la trh en el hecho de que la histidina central del trip\u00e9ptido es sustituida por \u00e1cido glut\u00e1mico, fenilalanina o glutamina (cockle, aitken, beg y smyth, 1989, j. Biol. Chem., 264,7788; khan, aitken, del rio-garcia y smuyh, 1992, j. Biol.  chem., 267,7464). Los p\u00e9ptidos trh-like se distribuyen fundamentalmente en aparato genital masculino y organos endocrinos en general, y en el sistema nervioso central (hipocampo, coliculo dorsal tronco cerebral (del rio-garcia y smyth, 1990, biochem. Soc. Trans., 18,434 y 1990, j. Endocrinol., 127,445). La aparici\u00f3n de p\u00e9ptidos trh-like en el sistema nervioso central nos llevo a planteamos la posibilidad de que estos p\u00e9ptidos tengan una actividad biol\u00f3gica central. Se sabe que la trh ejerce un efecto estimulante sobre la actividad locomotora as\u00ed como otras conductas excitatorias. El objetivo fundamental de este trabajo es comprobar el efecto que los p\u00e9ptidos trh-like tienen sobre la actividad locomotora y otras conductas excitatorias, estudiar su similitud o no con los efectos de la trh, adem\u00e1s de conocer los mecanismos de acci\u00f3n por los que se producen estos efectos. Se utilizaron ratas sprague-dawley adultas a las que se les implant\u00f3 una canula en el ventr\u00edculo lateral a traves de la cual se administraron los p\u00e9ptidos trh-like, pglu-glu-pro amida y pglu-phe-pro amida, a las dosis de 1, 10 y 100 ug, as\u00ed como trh que nos sirvi\u00f3 de comparaci\u00f3n. Los tres p\u00e9ptidos producen un incremento en la actividad locomotora que es dosis-dependiente. Cuando comparamos las acciones de los tres p\u00e9ptidos, a\u00fan produciendo un efecto total similar, aumentan la actividad locomotora de forma distinta. Con la dosis de 10 ug el efecto es mas tard\u00edo en el caso de trh.  con la dosis de 1 ug las diferencias son a\u00fan m\u00e1s notables, mientras pglu-phe-pro amida<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efectos de los peptidos trh-like,pglu-glu-pro amida y pglu-phe-pro amida. sobre la conducta motora de la rata.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efectos de los peptidos trh-like,pglu-glu-pro amida y pglu-phe-pro amida. sobre la conducta motora de la rata. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Rosa Mar\u00eda Sanchez Alonso <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Murcia<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Rio Garcia Jes\u00fas Del<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Brugger Auban Arturo Jose <\/li>\n<li> Serrano Molina Jos\u00e9 S. (vocal)<\/li>\n<li>George Smyth Derek (vocal)<\/li>\n<li>Demetrio Barcia Salorio (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Rosa Mar\u00eda Sanchez Alonso Recientemente se ha descrito la existencia de tres an\u00e1logos naturales de la trh [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[44,9,189,957,8235],"tags":[43700,463,93826,76364,93825,54041],"class_list":["post-34982","post","type-post","status-publish","format-standard","hentry","category-accion-de-los-farmacos","category-ciencias-medicas","category-farmacodinamia","category-farmacologia","category-murcia","tag-brugger-auban-arturo-jose","tag-demetrio-barcia-salorio","tag-george-smyth-derek","tag-rio-garcia-jesus-del","tag-rosa-maria-sanchez-alonso","tag-serrano-molina-jose-s"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/34982","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=34982"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/34982\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=34982"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=34982"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=34982"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}