{"id":35113,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/biosintesis-de-mitramicina-en-streptomyces-argillaceus-caracterizacion-de-genes-implicados-en-la-regulacion-y-la-biosintesis-de-los-26-dideoxiazucares\/"},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"biosintesis-de-mitramicina-en-streptomyces-argillaceus-caracterizacion-de-genes-implicados-en-la-regulacion-y-la-biosintesis-de-los-26-dideoxiazucares","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/biosintesis-de-mitramicina-en-streptomyces-argillaceus-caracterizacion-de-genes-implicados-en-la-regulacion-y-la-biosintesis-de-los-26-dideoxiazucares\/","title":{"rendered":"Biosintesis de mitramicina en streptomyces argillaceus: caracterizacion de genes implicados en la regulacion y la biosintesis de los 2,6-dideoxiazucares."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Lombo Brugos Felipe A. <\/strong><\/h2>\n<p>En la presente tesis se describe el aislamiento, a partir de la especie streptomyces argillaceus atcc 12956, de dos zonas del adn implicadas en la bios\u00edntesis del antitumoral mitramicina.  -una regi\u00f3n en la que un gen denominado mtmr codifica una prote\u00edna que act\u00faa como un regulador positivo de la producci\u00f3n de mitramicina.  -una segunda regi\u00f3n en la que se han secuenciado otros dos genes, mtmd y mtme, que codifican una dtdp-d-glucosa sintasa y una dtdp-d-glucosa 4,6-deshidratasa respectivamente, implicadas en la bios\u00edntesis de los 2,6-dideoxiaz\u00facares.  la mutaci\u00f3n en el gen mtmd ha posibilitado el aislamiento de una nueva mol\u00e9cula, denominada premitramicinona.  finalmente, utilizando los genes tcmh y tcmg, que codifican una monooxigenasa y una bioxigenasa de la ruta de bios\u00edntesis de tetracenomicina c en streptomyces glaucescens se ha logrado la modificaci\u00f3n de la premitramicinona, obteni\u00e9ndose premitramicinona h.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Biosintesis de mitramicina en streptomyces argillaceus: caracterizacion de genes implicados en la regulacion y la biosintesis de los 2,6-dideoxiazucares.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Biosintesis de mitramicina en streptomyces argillaceus: caracterizacion de genes implicados en la regulacion y la biosintesis de los 2,6-dideoxiazucares. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Lombo Brugos Felipe A. <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Oviedo<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>M\u00aa Del Carmen M\u00e9ndez Fern\u00e1ndez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  Evaristo Suarez Fernandez <\/li>\n<li> Gil Santos Jos\u00e9 A. (vocal)<\/li>\n<li>Francisco Malpartida Romero (vocal)<\/li>\n<li>Antonio Jimenez-Martinez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Lombo Brugos Felipe A. En la presente tesis se describe el aislamiento, a partir de la especie [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[2193,160,115,35,278,8846,17],"tags":[9593,9322,94048,8952,94047,14988],"class_list":["post-35113","post","type-post","status-publish","format-standard","hentry","category-antibioticos","category-bioquimica","category-bioquimica-molecular","category-ciencias-de-la-vida","category-microbiologia","category-oviedo","category-quimica","tag-antonio-jimenez-Martinez","tag-francisco-malpartida-romero","tag-gil-santos-jose-a","tag-juan-evaristo-suarez-fernandez","tag-lombo-brugos-felipe-a","tag-ma-del-carmen-mendez-fernandez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/35113","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=35113"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/35113\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=35113"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=35113"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=35113"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}