{"id":35122,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/analisis-de-la-expresion-del-pepsinogeno-c-y-su-regulacion-hormonal-en-carcinomas-humanos\/"},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"analisis-de-la-expresion-del-pepsinogeno-c-y-su-regulacion-hormonal-en-carcinomas-humanos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/analisis-de-la-expresion-del-pepsinogeno-c-y-su-regulacion-hormonal-en-carcinomas-humanos\/","title":{"rendered":"Analisis de la expresion del pepsinogeno c y su regulacion hormonal en carcinomas humanos."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Antonio Martinez Merino <\/strong><\/h2>\n<p>Introducci\u00f3n: el pepsin\u00f3geno c es una aspartil-proteinasa sintetizada principalmente por la mucosa g\u00e1strica. Sin embargo est\u00e1 presente en un 30% de los carcinomas de mama en donde, adem\u00e1s, andr\u00f3genos glucocorticoides y progest\u00e1genos regulan su expresi\u00f3n.  objetivos: realizar un extenso an\u00e1lisis inmunohistoqu\u00edmico de la expresi\u00f3n del pepsin\u00f3geno c en carcinomas humanos y su relaci\u00f3n con diversas caracter\u00edsticas morfol\u00f3gicas de los tumores y el estado de los receptores de andr\u00f3genos.  material y m\u00e9todos: se examina mediante el m\u00e9todo inmunohistoqu\u00edmico de biotina-estreptavidina, la capacidad de producir pepsin\u00f3geno c en una amplia variedad de carcinomas humanos en relaci\u00f3n a sus caracter\u00edsticas morfol\u00f3gicas, as\u00ed como el estado de los receptores de andr\u00f3genos por el mismo m\u00e9todo.  resultados: de 312 tumores, 109(34,9%) mostraron tinci\u00f3n positiva para el pepsin\u00f3geno c. Esto ocurri\u00f3 en los g\u00e1stricos, pancre\u00e1ticos, renales, prost\u00e1ticos, vesicales, endometriales, ov\u00e1ricos y melanomas. No mostraron tinci\u00f3n positiva los colo-rectales, de cervix uterino, pulm\u00f3n o basocelulares. La expresi\u00f3n de pepsin\u00f3geno c estuvo asociada con una buena diferenciaci\u00f3n histol\u00f3gica en los de est\u00f3mago, pr\u00f3stata, mama de var\u00f3n y endometrio. Se encontr\u00f3 tinci\u00f3n positiva para receptores de andr\u00f3genos en carcinomas de mama, endometrio, ovario, pr\u00f3stata y melanomas. No se encontr\u00f3 relaci\u00f3n significativa entre la expresi\u00f3n de pepsin\u00f3geno c y los receptores de andr\u00f3genos.  conclusiones: el pepsin\u00f3geno c puede ser expresado por una gran variedad de carcinomas. Su expresi\u00f3n se asocia con caracter\u00edsticas de menor agresividad y puede estar relacionada con posibles alteraciones hormonales asociadas con el desarrollo tumoral.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Analisis de la expresion del pepsinogeno c y su regulacion hormonal en carcinomas humanos.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Analisis de la expresion del pepsinogeno c y su regulacion hormonal en carcinomas humanos. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Antonio Martinez Merino <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Oviedo<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Carlos Lopez Otin<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Pedro Sanchez Lazo <\/li>\n<li>\u00e1lvaro Larrad Jim\u00e9nez (vocal)<\/li>\n<li>\u00c1lvaro Ruibal Morell (vocal)<\/li>\n<li>Andr\u00e9s Sampedro Nu\u00f1o (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Antonio Martinez Merino Introducci\u00f3n: el pepsin\u00f3geno c es una aspartil-proteinasa sintetizada principalmente por la mucosa g\u00e1strica. Sin [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[160,115,8846,17],"tags":[9734,7918,25308,94061,5834,10659],"class_list":["post-35122","post","type-post","status-publish","format-standard","hentry","category-bioquimica","category-bioquimica-molecular","category-oviedo","category-quimica","tag-alvaro-larrad-jimenez","tag-alvaro-ruibal-morell","tag-andres-sampedro-nuno","tag-antonio-Martinez-merino","tag-carlos-lopez-otin","tag-pedro-sanchez-lazo"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/35122","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=35122"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/35122\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=35122"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=35122"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=35122"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}