{"id":35125,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/expresion-de-los-genes-del-receptor-de-la-hormona-de-crecimiento-gh-r-y-del-factor-de-crecimiento-insulin-like-y-igf-i-en-higado-de-ratas-uremicas-influencia-de-la-malnutricion\/"},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"expresion-de-los-genes-del-receptor-de-la-hormona-de-crecimiento-gh-r-y-del-factor-de-crecimiento-insulin-like-y-igf-i-en-higado-de-ratas-uremicas-influencia-de-la-malnutricion","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-agrarias\/expresion-de-los-genes-del-receptor-de-la-hormona-de-crecimiento-gh-r-y-del-factor-de-crecimiento-insulin-like-y-igf-i-en-higado-de-ratas-uremicas-influencia-de-la-malnutricion\/","title":{"rendered":"Expresion de los genes del receptor de la hormona de crecimiento (gh-r) y del factor de crecimiento \u00abinsulin-like\u00bb y (igf-i) en higado de ratas uremicas. influencia de la malnutricion."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Venancio Martinez Suarez <\/strong><\/h2>\n<p>Las bases moleculares de la resistencia a la gh en el fallo renal cr\u00f3nico son desconocidas. En su origen pudiera estar implicado un descenso en el n\u00famero de receptores hep\u00e1ticos de gh y, como consecuencia, de la s\u00edntesis hep\u00e1tica de igf-i. Adem\u00e1s, la malnutrici\u00f3n que frecuentemente complica la situaci\u00f3n de uremia pudiera jugar alg\u00fan papel.  para investigar las modificaciones inducidas por el fallo renal cr\u00f3nico en la expresi\u00f3n hep\u00e1tica del gen de gh-r y del gen de igf-i medimos mediante northern blot los niveles de sus mrna espec\u00edficos en ratas macho s-d de 26 +-1 d\u00edas, sometidas a nefrectom\u00eda en dos tiempos de 5\/6 de su masa renal (nx, n-9). Comparamos estos resultados con los obtenidos en 3 grupos de ratas operadas \u00absham\u00bb y alimentadas \u00abad libitum\u00bb (controles sal, n=9), sometidas al mismo d\u00e9ficit nutritivo cal\u00f3rico-prote\u00edco que las nx pero con funci\u00f3n renal normal (malnutrici\u00f3n cal\u00f3rico- proteica, spf, n=7) y sometidas a d\u00e9ficit proteico similar a las nx y aporte cal\u00f3rico normal (malnutrici\u00f3n proteica, spf+, n=8).  las ratas nx desarrollaron uremia avanzada (sun 106 mg\/dl) y fueron hipocrecidas, con menores ganancias de peso (73%) y talla (62%) que los controles.  la expresi\u00f3n hep\u00e1tica de los genes de gh-r y de igf-i fue claramente menor en las ratas con uremia severa, siendo la malnutrici\u00f3n proteica la responsable principal de esta inhibici\u00f3n. Para ambos genes se pudo constatar un control transcripcional diferencial de los transcriptos analizados, siendo destacable la influencia de la ingesta cal\u00f3rica sobre el transcripto de 7,5 kb del gen de igf-i.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Expresion de los genes del receptor de la hormona de crecimiento (gh-r) y del factor de crecimiento \u00abinsulin-like\u00bb y (igf-i) en higado de ratas uremicas. influencia de la malnutricion.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Expresion de los genes del receptor de la hormona de crecimiento (gh-r) y del factor de crecimiento \u00abinsulin-like\u00bb y (igf-i) en higado de ratas uremicas. influencia de la malnutricion. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Venancio Martinez Suarez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Oviedo<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Fernando Santos Rodr\u00edguez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Manuel Crespo Hernandez <\/li>\n<li>Mar\u00eda no Rodriguez Portillo (vocal)<\/li>\n<li>Juan  Evaristo Suarez Fernandez (vocal)<\/li>\n<li>Roberto Hernandez Marco (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Venancio Martinez Suarez Las bases moleculares de la resistencia a la gh en el fallo renal cr\u00f3nico [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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