{"id":35166,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/modulacion-por-esteroides-del-efecto-producido-por-el-dago-agonista-mu-opioide-en-la-preparacion-de-hipocampo-de-raton-in-vitro\/"},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"modulacion-por-esteroides-del-efecto-producido-por-el-dago-agonista-mu-opioide-en-la-preparacion-de-hipocampo-de-raton-in-vitro","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/modulacion-por-esteroides-del-efecto-producido-por-el-dago-agonista-mu-opioide-en-la-preparacion-de-hipocampo-de-raton-in-vitro\/","title":{"rendered":"Modulacion por esteroides del efecto producido por el dago (agonista mu opioide) en la preparacion de hipocampo de raton \u00abin vitro\u00bb."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  San Martin Gines Simone <\/strong><\/h2>\n<p>Los esteroides producen en el sistema nervioso central efectos gen\u00f3micos cl\u00e1sicos e interacciones con receptores de membrana plasm\u00e1tica. Con respecto a estos efectos no-gen\u00f3micos, estudios recientes sugieren la acci\u00f3n de esteroides sobre receptores opioides. Se observ\u00f3 que el acetato de ciproterona (acp) y el dietilestilbestrol (des) pero no flutamida desplazan la uni\u00f3n de (3h) diprenorfina (antagonista opioide no selectivo) y3 (h)dago (agonista  opioide). Estos efectos sobre el receptor  , fueron estudiados a trav\u00e9s de potenciales evocados de la regi\u00f3n ca1 del stratum pyramidale de hipocampo de rat\u00f3n. Se observ\u00f3 una correlaci\u00f3n funcional de los efectos obtenidos con los dos f\u00e1rmacos desplazantes. Cpa se comport\u00f3 como antagonista del efecto amplificador y del efecto inhibidor observado en algunas situaciones experimentales (l\u00edquido nutricio con 1.2 mm de mgso4 o tras hipoxia transitoria) por dago. Des present\u00f3 un efecto gen\u00f3mico por medio del cual aumenta la amplitud de los potenciales evocados modificando la respuesta del receptor opioide despu\u00e9s de ser activado por dago, y otro efecto no-gen\u00f3mico, inhibiendo la amplitud de los potenciales evocados mediando efectos a trav\u00e9s de receptores opioides (al menos tipo mu) ya que su efecto no fu\u00e9 antagonizado por naloxona. Se puede concluir que los esteroides estudiados interact\u00faan con receptores opioides y generan respuestas espec\u00edficas y distintas entre ellos al actuar sobre los receptores opioides mu en cortes de hipocampo de rat\u00f3n. Por otro lado, hemos caracterizado un efecto inhibidor sobre la amplitud de los potenciales evocados, posiblemente debido a una acci\u00f3n directa de dago sobre receptores opioides ubicados fuera de las interneuronas, posiblemente en neuronas piramidales.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Modulacion por esteroides del efecto producido por el dago (agonista mu opioide) en la preparacion de hipocampo de raton \u00abin vitro\u00bb.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Modulacion por esteroides del efecto producido por el dago (agonista mu opioide) en la preparacion de hipocampo de raton \u00abin vitro\u00bb. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  San Martin Gines Simone <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Oviedo<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ana Isabel Baamonde Arbaiza<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Andres Rodriguez-trelles Fernando De <\/li>\n<li>Angela Alsasua Del Valle (vocal)<\/li>\n<li>Agustin Hidalgo Balsera (vocal)<\/li>\n<li>Manuel Mart\u00ednez Esteban (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de San Martin Gines Simone Los esteroides producen en el sistema nervioso central efectos gen\u00f3micos cl\u00e1sicos e interacciones [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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