{"id":35188,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/expresion-y-significacion-clinica-de-la-apolipoproteina-d-el-pepsinogeno-c-y-la-colagenasa-3-en-los-tumores-de-origen-ginecologico\/"},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"expresion-y-significacion-clinica-de-la-apolipoproteina-d-el-pepsinogeno-c-y-la-colagenasa-3-en-los-tumores-de-origen-ginecologico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/expresion-y-significacion-clinica-de-la-apolipoproteina-d-el-pepsinogeno-c-y-la-colagenasa-3-en-los-tumores-de-origen-ginecologico\/","title":{"rendered":"Expresion y significacion clinica de la apolipoproteina d, el pepsinogeno c y la colagenasa 3 en los tumores de origen ginecologico."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Julio Vazquez Rojo <\/strong><\/h2>\n<p>Se analiza la expresi\u00f3n de apolipoprote\u00edna d, pepsin\u00f3geno c y colagenasa 3 en 58 tumores de endometrio, 72 carcinomas epiteliales de ovario y 8 carcinomas escamosos de c\u00e9rvix mediante an\u00e1lisis inmunohistoqu\u00edmico. Este an\u00e1lisis localiz\u00f3 a las 3 prote\u00ednas en el citoplasma de las c\u00e9lulas tumorales excepto la apolipoprote\u00edna d que tambi\u00e9n se situ\u00f3 en los fibroblastos del estroma.  en los tumores de endometrio, el 34% fueron positivos para la apolipoprote\u00edna d y no se asoci\u00f3 a ninguna caracter\u00edstica de las pacientes ni de los tumores. El 36% fueron positivos para el pepsin\u00f3geno c y el 51% para la colagenasa 3 y se asociaron significativamente con la infiltraci\u00f3n miometrial de forma que a mayor infiltraci\u00f3n miometrial, menor expresi\u00f3n de pepsin\u00f3geno c y mayor de colagenasa 3.  en los carcinomas epiteliales de ovario, el 27% fueron positivos para la apolipoprote\u00edna d y las pacientes con tumor residual mayor de 1 cm. Ten\u00edan una menor supervivencia cuando sus tumores eran negativos para la prote\u00edna, de forma significativa. El 26% fueron positivos para el pepsin\u00f3geno c y las pacientes con niveles s\u00e9ricos preoperatorios de ca 125 negativos ten\u00edan un menor tiempo libre de enfermedad y una menor supervivencia cuando los tumores eran negativos para el pepsin\u00f3geno c. El 22% de los tumores de ovario fueron positivos para la colagenasa 3 y se asoci\u00f3 significativamente con el tama\u00f1o del tumor inicial pero no con el pron\u00f3stico de las pacientes.  la totalidad de los carcinomas escamosos de c\u00e9rvix fueron negativos para la apolipoprote\u00edna d y el pepsin\u00f3geno c y el 37% fueron positivos para la colagenasa 3.  conclusi\u00f3n: la expresi\u00f3n de apolipoprote\u00edna d y pepsin\u00f3geno c en los tumores ginecol\u00f3gicos parece asociarse a un comportamiento tumoral menos agresivo y la expresi\u00f3n de colagenasa 3 a un comportamiento tumoral m\u00e1s agresivo.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Expresion y significacion clinica de la apolipoproteina d, el pepsinogeno c y la colagenasa 3 en los tumores de origen ginecologico.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Expresion y significacion clinica de la apolipoproteina d, el pepsinogeno c y la colagenasa 3 en los tumores de origen ginecologico. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Julio Vazquez Rojo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Oviedo<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisco Vizoso Pi\u00f1eiro<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Carlos Lopez Otin <\/li>\n<li>\u00c1lvaro Ruibal Morell (vocal)<\/li>\n<li>Jos\u00e9 Antonio Vega  Alvarez (vocal)<\/li>\n<li>Jos\u00e9 Schneider Fontan (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Julio Vazquez Rojo Se analiza la expresi\u00f3n de apolipoprote\u00edna d, pepsin\u00f3geno c y colagenasa 3 en 58 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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