{"id":35199,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-del-trasplante-autologo-de-celulas-progenitoras-hematopoyeticas-en-la-genesis-de-mielodisplasia-y-leucemias-agudas-secundarias\/"},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"papel-del-trasplante-autologo-de-celulas-progenitoras-hematopoyeticas-en-la-genesis-de-mielodisplasia-y-leucemias-agudas-secundarias","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/papel-del-trasplante-autologo-de-celulas-progenitoras-hematopoyeticas-en-la-genesis-de-mielodisplasia-y-leucemias-agudas-secundarias\/","title":{"rendered":"Papel del trasplante autologo de celulas progenitoras hematopoyeticas en la genesis de mielodisplasia y leucemias agudas secundarias."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Amigo Lozano M. Luz <\/strong><\/h2>\n<p>Este trabajo se divide en dos partes diferentes:  en la primera parte los objetivos eran conocer la incidencia de los s\u00edndromes mielodispl\u00e1sicos (smd) y leucemias agudas (la) secundarias postrasplante aut\u00f3logo de progenitores hematopoy\u00e9ticos en nuestro medio, las caracter\u00edsticas de estos pacientes y los factores que pod\u00edan contribuir a su aparici\u00f3n. En aquellos casos con smd \u00f3 la secundarios que tuvieran alteraciones citogen\u00e9ticas, se investig\u00f3 si la alteraci\u00f3n clonal pod\u00eda existir en las c\u00e9lulas hematopoy\u00e9ticas antes del trasplante mediante la t\u00e9cnica de hibridaci\u00f3n in situ. La incidencia en nuestro medio (1,12%) es similar a la de la literatura. Los pacientes que desarrollaron estas complicaciones hab\u00edan recibido una dosis de agentes alquilantes significativamente mayor que el resto de los pacientes. Cuando se utilizaron progenitores de sangre perif\u00e9rica el tiempo transcurrido desde el trasplante al diagn\u00f3stico del smd \u00f3 la fue m\u00e1s corto que cuando se utiliz\u00f3 m\u00e9dula \u00f3sea. Al menos en algunos casos, la alteraci\u00f3n clonal existe en los progenitores hematopoy\u00e9ticos antes del trasplante.  en la segunda parte se realiz\u00f3 un estudio retrospectivo en una serie de 214 pacientes sometidos a trasplante aut\u00f3logo en el hospital universitario de salamanca.  comprobamos que el trasplante aut\u00f3logo aumenta el n\u00famero de casos con citopenias perif\u00e9ricas y es la cifra de plaquetas sobre la que ejerce mayor influencia. El n\u00famero de c\u00e9lulas infundido condiciona las caracter\u00edsticas del injerto a largo plazo. Tanto pre como postrasplante existen dishemopoyesis y alteraci\u00f3n en el crecimiento in vitro de los progenitores hematopoy\u00e9ticos, por lo tanto, estos datos no nos sirven para la detecci\u00f3n precoz de los smd postrasplante. Los criterios del grupo cooperativo franco- americano-brit\u00e1nico no son v\u00e1lidos para el diagn\u00f3stico de los smd postrasplante y se hacen necesarios otros par\u00e1metros como estudios citogen\u00e9tic<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel del trasplante autologo de celulas progenitoras hematopoyeticas en la genesis de mielodisplasia y leucemias agudas secundarias.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel del trasplante autologo de celulas progenitoras hematopoyeticas en la genesis de mielodisplasia y leucemias agudas secundarias. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Amigo Lozano M. Luz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda  Consuelo Juan a Del Ca\u00f1izo Fernandez Roldan<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Agustin Rios Gonzalez <\/li>\n<li>Adrian Alegre Amor (vocal)<\/li>\n<li>Fernando Hern\u00e1ndez Navarro (vocal)<\/li>\n<li>Enric Carreras (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Amigo Lozano M. Luz Este trabajo se divide en dos partes diferentes: en la primera parte los [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,218,139,9386],"tags":[25054,9428,94184,87793,8245,9401],"class_list":["post-35199","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-hematologia","category-medicina-interna","category-salamanca","tag-adrian-alegre-amor","tag-agustin-rios-gonzalez","tag-amigo-lozano-m-luz","tag-enric-carreras","tag-fernando-hernandez-navarro","tag-maria-consuelo-juan-a-del-canizo-fernandez-roldan"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/35199","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=35199"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/35199\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=35199"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=35199"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=35199"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}