{"id":35272,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/alteraciones-numericas-de-cromosomas-y-expresion-de-mdr-como-factores-pronosticos-en-el-mieloma-multiple\/"},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"alteraciones-numericas-de-cromosomas-y-expresion-de-mdr-como-factores-pronosticos-en-el-mieloma-multiple","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/alteraciones-numericas-de-cromosomas-y-expresion-de-mdr-como-factores-pronosticos-en-el-mieloma-multiple\/","title":{"rendered":"Alteraciones numericas de cromosomas y expresion de mdr como factores pronosticos en el mieloma multiple."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jos\u00e9 Antonio P\u00e9rez Sim\u00f3n <\/strong><\/h2>\n<p>En el presente estudio, centrado en el an\u00e1lisis de factores pron\u00f3sticos en el mieloma m\u00faltiple relaccionados con las caracter\u00edsticas biol\u00f3gicas de las celulas plasmaticas hemos analizado, en un total de 86 pacientes, el valor pron\u00f3stico y la incidencia de las alteraciones num\u00e9ricas de cromosomas y la expresi\u00f3n del fenotipo de resistencia a m\u00faltiples drogas (mdri) en el mieloma.  la incidencia de alteraciones num\u00e9ricas de cromosomas en nuestro estudio alcanz\u00f3 el 70%, siendo los cromosomas m\u00e1s frecuentemente implicados en alteraciones num\u00e9ricas los cromosomas 9, 1 y 15, siendo especialmente frecuente la monosomia del cromosoma 13. La presencia de trisom\u00eda de los cromosomas 6, 9 y 17 se asoci\u00f3 con un pron\u00f3stico favorable, mientras que los pacientes portadores de monosom\u00eda del cromosoma 13 presentaban una supervivencia significativamente m\u00e1s corta.  por otro lado, en los 40 pacientes en los que se analiz\u00f3 la expresi\u00f3n de mdri en el momento del diagn\u00f3stico, la mediana de eliminaci\u00f3n de rodamina intracelular fue del 61%. La expresi\u00f3n de mdri se relacion\u00f3 con factores cl\u00ednicos y biol\u00f3gicos de mal pron\u00f3stico, como niveles bajos de alb\u00famina y altos de creatinina y calcio, as\u00ed como una afectaci\u00f3n \u00f3sea y un estad\u00edo cl\u00ednico m\u00e1s avanzados, si bien estos datos no se tradujeron en diferencias en cuanto a la supervivencia.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Alteraciones numericas de cromosomas y expresion de mdr como factores pronosticos en el mieloma multiple.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Alteraciones numericas de cromosomas y expresion de mdr como factores pronosticos en el mieloma multiple. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jos\u00e9 Antonio P\u00e9rez Sim\u00f3n <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Alberto Orfao De Matos Correia E Vale<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Antonio Lopez borrasca <\/li>\n<li>eduardo Rocha (vocal)<\/li>\n<li>agustin Caro paton gomez (vocal)<\/li>\n<li>joan Blade (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jos\u00e9 Antonio P\u00e9rez Sim\u00f3n En el presente estudio, centrado en el an\u00e1lisis de factores pron\u00f3sticos en el [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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