{"id":35336,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/desarrollo-de-un-sistema-de-liberacion-intraocular-de-5-fluorouridina\/"},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"desarrollo-de-un-sistema-de-liberacion-intraocular-de-5-fluorouridina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/desarrollo-de-un-sistema-de-liberacion-intraocular-de-5-fluorouridina\/","title":{"rendered":"Desarrollo de un sistema de liberacion intraocular de 5-fluorouridina."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Dorta Castro M. Jes\u00fas <\/strong><\/h2>\n<p>El objetivo de esta tesis es el desarrollo de un sistema de cesi\u00f3n sostenida intraocular biodegradable que delibere 5-fur durante un periodo de 7 a 15 d\u00edas. Los pasos a desarrollar ser\u00edan: estudio de la estabilidad de la 5-fur en disoluci\u00f3n, elaboraci\u00f3n y caracterizaci\u00f3n de las microesferas in vitro y la elaboraci\u00f3n y caracterizaci\u00f3n de los implantes in vitro. Se obtuvieron las siguientes conclusiones:  &#8211; se puso de manifiesto la inestabilidad de la 5-fur, indetific\u00e1ndose como productos de degradaci\u00f3n mediante rmn-h elevado 1 el 5-fu y la d-ribosa.  &#8211; la cin\u00e9tica de degradaci\u00f3n identificada incluye un proceso de cat\u00e1lisis mediada por el producto de degradaci\u00f3n 5-fu, si bien el mecanismo de degradaci\u00f3n no fue elucidado.  &#8211; como factores condicionantes de la estabilidad de la 5-fur, hemos de considerar al menos la presencia de los pol\u00edmeros derivados de los \u00e1cidos l\u00e1ctico y glic\u00f3lico.  &#8211; la elevada solubilidad de la 5-fur no permite ni una encapsulaci\u00f3n eficaz ni modular la cesi\u00f3n del principio activo a partir de microesferas.  &#8211; la cesi\u00f3n de 5-fur a partir de implantes recubiertos de plga (mw:37000 y 135000) de 5 mm de di\u00e1metro y 1 mm de espesor y desde implantes recubiertos de plga-peg (400) (mw: 24000) y de plga-mpeg (5000) (mw: 48000) de 3 mm de di\u00e1metro y 1 mm de espesor, satisface el requisito de tiempo de cesi\u00f3n in vitro establecido.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Desarrollo de un sistema de liberacion intraocular de 5-fluorouridina.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Desarrollo de un sistema de liberacion intraocular de 5-fluorouridina. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Dorta Castro M. Jes\u00fas <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 La laguna<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Matias A. Llabres Martinez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: ram\u00f3n Mart\u00ednez pacheco <\/li>\n<li>victor Martin garcia (vocal)<\/li>\n<li>Jos\u00e9 Domenech berrozpe (vocal)<\/li>\n<li>Manuel Barrera niebla (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Dorta Castro M. Jes\u00fas El objetivo de esta tesis es el desarrollo de un sistema de cesi\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,957,9915],"tags":[94446,13795,94448,26005,3307,94447],"class_list":["post-35336","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-farmacologia","category-la-laguna","tag-dorta-castro-m-jesus","tag-jose-domenech-berrozpe","tag-manuel-barrera-niebla","tag-matias-a-llabres-Martinez","tag-ramon-Martinez-pacheco","tag-victor-martin-garcia"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/35336","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=35336"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/35336\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=35336"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=35336"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=35336"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}