{"id":35372,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-de-los-linfocitos-t-en-la-patogenia-de-la-arteritis-de-celulas-gigantes-y-polimialgia-reumatica\/"},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"papel-de-los-linfocitos-t-en-la-patogenia-de-la-arteritis-de-celulas-gigantes-y-polimialgia-reumatica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/papel-de-los-linfocitos-t-en-la-patogenia-de-la-arteritis-de-celulas-gigantes-y-polimialgia-reumatica\/","title":{"rendered":"Papel de los linfocitos t en la patogenia de la arteritis de celulas gigantes y polimialgia reumatica."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Victor Martinez Taboada <\/strong><\/h2>\n<p>Proposito: 1) caracterizar la respuesta inmune celular mediada por linfocitos tcd4+ en el infiltrado inflamatorio de arteria temporal (at) en pacientes con acg. 2) establecimiento de un modelo experimental de acg.  3) evaluar el papel de los linfocitos t cd8+ en el desarrollo de la pmr y la acg:  metodos: an\u00e1lisis del repertorio de tcr por mac anti-vbeta, \u00abspectrotyping\u00bb, y secuenciaci\u00f3n directa.  utilizaci\u00f3n de ratones scid para el establecimiento de un m\u00e9todo in vivo de estudio de la acg por medio del xeno-injerto de fragmentos de at.  resultados: 1) la respuesta inmune en el infiltrado inflamatorio vascular est\u00e1 mediada por linfocitos tcd4+, a) la proliferaci\u00f3n clonal de determinadas poblaciones de linfocitos tcd4+ en las lesiones vascul\u00edticas es un fen\u00f3meno frecuente. B) la gran mayoria de los pacientes con acg presentan un peque\u00f1o porcentaje de linfocitos t cd4+ expandidos en diferentes porciones del infiltrado inflamatorio. C) los distintos pacientes utilizan mol\u00e9culas de tcr diferentes para el reconocimiento antig\u00e9nico. D) las cdr3 de los clones de linfocitos t cd4+ expandidos en el infiltrado inflamatorio presentan unas caracteristicas moleculares distintivas. E) un ag localizado en la at de pacientes con acg y com\u00fan a distintos pacientes, induce la proliferaci\u00f3n de los linfocitos t cd4+ aislados de las lesiones vascul\u00edticas.  f) este ag est\u00e1 tambi\u00e9n presente en el tejido arterial de pacientes con pmr pero no en el at normal, lo que indica que no es un componente constitutivo de la at. 2) validez del modelo experimental de acg. A) el infiltrado inflamatorio caracter\u00edstico persiste en los xeno-injertos. B) todos los componentes necesarios para mantener el proceso vascul\u00edtico se encuentran presentes en la at. C) determinadas poblaciones de linfocitos t cd4+ sobreviven en el infiltrado inflamatorio y sufren expansi\u00f3n clonal tras el injerto. D) linfocitos t cd4+ con id\u00e9nticas cdr3 son seleccionados en<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel de los linfocitos t en la patogenia de la arteritis de celulas gigantes y polimialgia reumatica.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel de los linfocitos t en la patogenia de la arteritis de celulas gigantes y polimialgia reumatica. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Victor Martinez Taboada <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Cantabria<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Vicente Rodriguez Valverde<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Berrazueta Fernandez Jos\u00e9 Ramon <\/li>\n<li>Armando Lafont Roca (vocal)<\/li>\n<li>Jos\u00e9 Antonio Amado Se\u00f1aris (vocal)<\/li>\n<li> Multher A. Khamashta Munther (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Victor Martinez Taboada Proposito: 1) caracterizar la respuesta inmune celular mediada por linfocitos tcd4+ en el infiltrado [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[10518,9,139,877],"tags":[94507,10627,10543,94508,10549,94506],"class_list":["post-35372","post","type-post","status-publish","format-standard","hentry","category-cantabria","category-ciencias-medicas","category-medicina-interna","category-reumatologia","tag-armando-lafont-roca","tag-berrazueta-fernandez-jose-ramon","tag-jose-antonio-amado-senaris","tag-multher-a-khamashta-munther","tag-vicente-rodriguez-valverde","tag-victor-Martinez-taboada"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/35372","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=35372"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/35372\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=35372"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=35372"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=35372"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}