{"id":35391,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-inmunohistoquimico-de-la-expresion-proteica-p-53-bck-2-c-erbb-2-y-del-antigeno-nuclear-ki-67-en-el-adenocarcinoma-renal-significacion-pronostica\/"},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"estudio-inmunohistoquimico-de-la-expresion-proteica-p-53-bck-2-c-erbb-2-y-del-antigeno-nuclear-ki-67-en-el-adenocarcinoma-renal-significacion-pronostica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-inmunohistoquimico-de-la-expresion-proteica-p-53-bck-2-c-erbb-2-y-del-antigeno-nuclear-ki-67-en-el-adenocarcinoma-renal-significacion-pronostica\/","title":{"rendered":"Estudio inmunohistoquimico de la expresion proteica p-53, bck-2, c-erbb-2 y del antigeno nuclear ki-67 en el adenocarcinoma renal. significacion pronostica."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Antonio Villanueva Pe\u00f1a <\/strong><\/h2>\n<p>El adenocarcinoma renal es un tumor de comportamiento relativamente impredecible. Se buscan factores pron\u00f3sticos v\u00e1lidos.  objetivos. Demostrar la validez pron\u00f3stica de la determinaci\u00f3n inmunohistoqu\u00edmica de productos celulares relacionados en mayor o menor medida con la proliferaci\u00f3n y muerte celular.  material y metodos. Presentamos una revisi\u00f3n de 85 adenocarcinomas renales tratados quir\u00fargicamente en el per\u00edodo 1970-1987. Se analiza la expresi\u00f3n proteica inmunohistoqu\u00edmica de las prote\u00ednas p-53, bcl-2, c-erbb-2 y ki-67 comparado con los datos de citometr\u00eda de flujo, el \u00edndice mit\u00f3tico y los resultados del estudio de microscopia cuantitativa.  resultados. No se encuentra relaci\u00f3n de la expresi\u00f3n de la prote\u00edna p-53 con el estadio patol\u00f3gico (tnm de la uicc de 1992 y robson) o tipo celular, aunque s\u00ed con el grado nuclear de fuhrman. La expresi\u00f3n de p-53 carece de valor pron\u00f3stico.  por el contrario, la prote\u00edna bcl-2 se relaciona inversamente con el \u00edndice mit\u00f3tico, el porcentaje de c\u00e9lulas en fase s y el \u00edndice de proliferaci\u00f3n celular.  no se encuentra relaci\u00f3n con el grado de estad\u00edos, pero resulta un factor pron\u00f3stico significativo.  la prote\u00edna c-erbb-2 no se relacion\u00f3 con ninguno de los par\u00e1metros anatomocl\u00ednicos convencionales ni con la supervivencia.  por el contrario, el porcentaje de c\u00e9lulas tumorales que mostraron inmunocreatividad para el ant\u00edgeno nuclear ki-67 se relacion\u00f3 con el grado, estad\u00edo tnm, robson, tipo celular, \u00edndice mit\u00f3tico e \u00edndice nucleolar. Se establecen dos grupos pron\u00f3sticos en funci\u00f3n de la expresi\u00f3n de ki-67. Los casos positivos tuvieron una supervivencia significativamente peor que los casos negativos. En el an\u00e1lisis multivariante de los factores con significaci\u00f3n pron\u00f3stica individual, el porcentaje de c\u00e9lulas ki-67 positivas resulta la tercera variable de m\u00e1s peso tras el \u00edndice nucleolar y el estad\u00edo tnm.  conclusiones: la determin<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio inmunohistoquimico de la expresion proteica p-53, bck-2, c-erbb-2 y del antigeno nuclear ki-67 en el adenocarcinoma renal. significacion pronostica.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio inmunohistoquimico de la expresion proteica p-53, bck-2, c-erbb-2 y del antigeno nuclear ki-67 en el adenocarcinoma renal. significacion pronostica. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Antonio Villanueva Pe\u00f1a <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Cantabria<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Fernando Val Bernal<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Manuel Arias Rodriguez <\/li>\n<li> Rivera Pomar Jos\u00e9 M. (vocal)<\/li>\n<li>Pablo Carretero Gonz\u00e1lez (vocal)<\/li>\n<li> Garijo Ayensa M. Francisca (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Antonio Villanueva Pe\u00f1a El adenocarcinoma renal es un tumor de comportamiento relativamente impredecible. Se buscan factores pron\u00f3sticos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[10518,9,52,156],"tags":[94542,10629,10583,21611,1046,26364],"class_list":["post-35391","post","type-post","status-publish","format-standard","hentry","category-cantabria","category-ciencias-medicas","category-histopatologia","category-patologia","tag-antonio-villanueva-pena","tag-garijo-ayensa-m-francisca","tag-jose-fernando-val-bernal","tag-manuel-arias-rodriguez","tag-pablo-carretero-gonzalez","tag-rivera-pomar-jose-m"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/35391","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=35391"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/35391\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=35391"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=35391"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=35391"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}