{"id":35397,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/proteina-inflamatoria-de-los-macrofagos-1-beta-mip-1beta-como-pirogeno-endogeno\/"},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"proteina-inflamatoria-de-los-macrofagos-1-beta-mip-1beta-como-pirogeno-endogeno","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/proteina-inflamatoria-de-los-macrofagos-1-beta-mip-1beta-como-pirogeno-endogeno\/","title":{"rendered":"Proteina inflamatoria de los macrofagos-1 beta (mip-1beta) como pirogeno endogeno."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Khalid Benamar <\/strong><\/h2>\n<p>La fiebre es el signo m\u00e1s aparente y mejor conocido de la infecci\u00f3n. Recientemente se ha descubierto, una nueva citocina pir\u00f3genica end\u00f3geno llamado la prote\u00edna inflamatoria de los macr\u00f3fagos -1beta (mip-1beta).  el presente estudio consiste en demostrar que mip-1beta cumple la mayor\u00eda de los criterios necesarios para ser un pir\u00f3geno end\u00f3geno:  1) la administraci\u00f3n central de 50 pg de mip-1beta produce un aumento significativo de la temperatura corporal (tc) dosis dependiente 2) el pretratamiento con inhibidores la s\u00edntesis de prostaglandinas (aines, glucocorticoides) no antagoniza, la respuesta febril de mip-1beta administrado centralmente 3) la administraci\u00f3n previa central de anticuerpos frente al de mip-1 bloquea totalmente la respuesta febril de los lipopolisac\u00e1rodos.  4) tras la administraci\u00f3n de lps se ha visto la presencia del mip-1beta en area pre\u00f3ptica del hipot\u00e1lamo anterior (po\/ha).  as\u00ed mismo el mip-1beta es un pir\u00f3geno end\u00f3geno el m\u00e1s potente conocido hasta el momento con un mecanismo de acci\u00f3n diferente e independiente del resto pde pir\u00f3genos end\u00f3genos conocidos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Proteina inflamatoria de los macrofagos-1 beta (mip-1beta) como pirogeno endogeno.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Proteina inflamatoria de los macrofagos-1 beta (mip-1beta) como pirogeno endogeno. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Khalid Benamar <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Sevilla<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Mi\u00f1ano Sanchez Francisco Javier<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Angel Armengol Butron De Mujica <\/li>\n<li>Manuel Sancribrian Morcillo (vocal)<\/li>\n<li>Diana Lopez Mendoza (vocal)<\/li>\n<li>Pablo Salinas S\u00e1nchez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Khalid Benamar La fiebre es el signo m\u00e1s aparente y mejor conocido de la infecci\u00f3n. Recientemente se [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,957,183,10715],"tags":[94551,10804,94549,94550,82605,7912],"class_list":["post-35397","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-farmacologia","category-farmacos-psicotropicos","category-sevilla","tag-diana-lopez-mendoza","tag-jose-angel-armengol-butron-de-mujica","tag-khalid-benamar","tag-manuel-sancribrian-morcillo","tag-minano-sanchez-francisco-javier","tag-pablo-salinas-sanchez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/35397","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=35397"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/35397\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=35397"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=35397"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=35397"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}