{"id":35430,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/diagnostico-de-la-tuberculosis-en-la-infancia-mediante-reaccion-en-cadena-de-la-polimerasa\/"},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"diagnostico-de-la-tuberculosis-en-la-infancia-mediante-reaccion-en-cadena-de-la-polimerasa","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/diagnostico-de-la-tuberculosis-en-la-infancia-mediante-reaccion-en-cadena-de-la-polimerasa\/","title":{"rendered":"Diagnostico de la tuberculosis en la infancia mediante reaccion en cadena de la polimerasa."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Gomez Pastrana Duran David <\/strong><\/h2>\n<p>Introduccion: el diagn\u00f3stico de la tuberculosis en la infancia suele realizarse en base a par\u00e1metros cl\u00ednicos debido a que la tinci\u00f3n directa suele ser negativa y el cultivo adem\u00e1s de requerir un tiempo prolongado para el aislamiento, tiene baja sensibilidad en estos pacientes.  objetivos: el prop\u00f3sito de este trabajo ha sido evaluar la reacci\u00f3n en cadena de la polimerasa (pcr) mediante reamplificaci\u00f3n como t\u00e9cnica diagn\u00f3stica en la tuberculosis pulmonar infantil, compararla con los m\u00e9todos diagn\u00f3sticos tradicionales y analizar su resultado en ni\u00f1os con infecci\u00f3n tuberculosa sin enfermedad aparente. Material y m\u00e9todos: hemos realizado de forma prospectiva baciloscopia, cultivo y pcr en 350 muestras cl\u00ednicas (aspirado g\u00e1strico y lavado broncoalveolar) procedentes de 117 ni\u00f1os entre enero de 1994 y diciembre de 1995. A todos los ni\u00f1os con infecci\u00f3n tuberculosa sin evidencia de enfermedad se les realiz\u00f3 tomograf\u00eda computarizada (tc) para la detecci\u00f3n de adenopat\u00edas que pudieran pasar desapercibidas en la radiograf\u00eda (rx) de t\u00f3rax. Resultados: la pcr tuvo mayor sensibilidad y valor predictivo negativo que el cultivo y la baciloscopia en el diagn\u00f3stico de tuberculosis activa.  la sensibilidad (s) de la pcr fue del 56.8% al tomar varias muestras cl\u00ednicas por paciente (cultivo s: 37.8%, baciloscopia s: 13.5%), aumentando si el ni\u00f1o se encontraba ingresado en el momento de la recogida de la muestra cl\u00ednica (s: 63.9%), si exist\u00eda tuberculosis endobronquial (s: 83.3%) y no se alter\u00f3 por la presencia de tratamiento antituberculoso. La mayor diferencia de sensibilidad a favor de la pcr respecto al cultivo, se encontr\u00f3 cuando exist\u00eda patr\u00f3n miliar, afectaci\u00f3n\/pleural y adenopat\u00eda hiliar en la radiograf\u00eda de t\u00f3rax. Todos los ni\u00f1os con infecci\u00f3n tuberculosa sin enfermedad aparente que tuvieron pcr positiva, presentaron adenopat\u00edas detectadas en la tc, que no eran visibles en la rx de t\u00f3rax. La especifi<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Diagnostico de la tuberculosis en la infancia mediante reaccion en cadena de la polimerasa.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Diagnostico de la tuberculosis en la infancia mediante reaccion en cadena de la polimerasa. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Gomez Pastrana Duran David <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Sevilla<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Rafael Torronteras Santiago<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Manuel Casal Roman <\/li>\n<li>Joaquin Ortiz Tardio (vocal)<\/li>\n<li>Jos\u00e9 Gonz\u00e1lez Hachero (vocal)<\/li>\n<li>Emilia Barrot Cortes (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Gomez Pastrana Duran David Introduccion: el diagn\u00f3stico de la tuberculosis en la infancia suele realizarse en base [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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