{"id":35432,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/diseno-y-elaboracion-de-un-nuevo-sistema-de-liberacion-programada\/"},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"diseno-y-elaboracion-de-un-nuevo-sistema-de-liberacion-programada","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/diseno-y-elaboracion-de-un-nuevo-sistema-de-liberacion-programada\/","title":{"rendered":"Dise\u00f1o y elaboracion de un nuevo sistema de liberacion programada."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda  Luisa Gonzalez Rodriguez <\/strong><\/h2>\n<p>El objetivo b\u00e1sico propuesto en la presente tesis doctoral se centra en el dise\u00f1o y elaboraci\u00f3n de un nuevo dispositivo de liberaci\u00f3n controlada, que cumpla una doble finalidad. Por una parte, conseguir niveles plasm\u00e1ticos de f\u00e1rmaco constantes en el organismo, mediante la consecuci\u00f3n de un proceso de liberaci\u00f3n que siga una cin\u00e9tica de orden cero. Por otra, asegurar la liberaci\u00f3n del f\u00e1rmaco en un determinado tramo del tracto gastrointestinal. El dispositivo consta de una esfera central donde va incluido el producto activo; \u00e9sta va englobada dentro de un sistema matricial compuesto por un pol\u00edmero insoluble y una sustancia canalizante, soluble, form\u00e1ndose un sistema matricial inerte. Se ha evaluado la influencia de algunas variables de formulaci\u00f3n sobre el mecanismo de liberaci\u00f3n que gobernar\u00e1, tanto el inicio como el proceso global de liberaci\u00f3n del f\u00e1rmaco. Se han obtenido tiempos de retardo muy variados, pudiendo oscilar entre los 10 y 270 minutos. Este hecho hace posible programar la liberaci\u00f3n en un determinado lugar del tracto digestivo, a voluntad del formulador.  modificando ciertas variables, ha sido posible modificar la velocidad de liberaci\u00f3n, oscilando los valores entre 120 y 560 minutos en cuanto al par\u00e1metro t50, y una duraci\u00f3n de los per\u00edodos de orden cero de hasta los 400 minutos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Dise\u00f1o y elaboracion de un nuevo sistema de liberacion programada.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Dise\u00f1o y elaboracion de un nuevo sistema de liberacion programada. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda  Luisa Gonzalez Rodriguez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Sevilla<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Rabasco Alvarez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Eugenio Sell\u00e9s Flores <\/li>\n<li> Torres Suarez Ana Isabel (vocal)<\/li>\n<li>Adamo Fini (vocal)<\/li>\n<li>Antonio Aguilar Ros (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Luisa Gonzalez Rodriguez El objetivo b\u00e1sico propuesto en la presente tesis doctoral se centra en el [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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