{"id":35506,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efectos-de-las-lipoproteinas-de-baja-densidad-sobre-los-neutrofilos-y-sobre-los-cristales-de-acido-urico\/"},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"efectos-de-las-lipoproteinas-de-baja-densidad-sobre-los-neutrofilos-y-sobre-los-cristales-de-acido-urico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/efectos-de-las-lipoproteinas-de-baja-densidad-sobre-los-neutrofilos-y-sobre-los-cristales-de-acido-urico\/","title":{"rendered":"Efectos de las lipoproteinas de baja densidad sobre los neutrofilos y sobre los cristales de acido urico."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Toyos Saenz De Miera Francisco Javier <\/strong><\/h2>\n<p>Cuando los cristales de \u00e1cido \u00farico, son preincubados con diversas concentraciones de ldl, y se emplean luego como est\u00edmulo de neutr\u00f3filos, la producci\u00f3n de super\u00f3xido disminuye de un modo dosis-dependiente (inhibici\u00f3n de un 79% con 100  g\/ml de ldl). Por el contrario, cuando se realiza adici\u00f3n simult\u00e1nea de ldl y cristales sobre la suspensi\u00f3n de neutr\u00f3filos o cuando se preincuban los neutr\u00f3filos con ldl y luego son estimulados con cristales de urato, la inhibici\u00f3n de la producci\u00f3n de super\u00f3xido no supera el 5% (p 0.1). Estos datos confirman que la forma de inhibici\u00f3n de la ldl se produce al recubrir al cristal e impedir de esta forma que interaccione directamente con el neutr\u00f3filo. Al estimular los polimorfonucleares con acetil-ldl la producci\u00f3n de super\u00f3xido es pr\u00e1cticamente inexistente. La adicci\u00f3n simult\u00e1nea de acetil-ldl y fmlp no modifica la producci\u00f3n de super\u00f3xido por los neutr\u00f3filos estimulados. Cuando los neutr\u00f3filos son estimulados con acetil-ldl se produce una ligera liberaci\u00f3n de lisozima y de beta-glucuronidasa que no se incrementa al a\u00f1adir citocalasina b. Al actuar sobre los neutr\u00f3filos, tanto las ldl como las acetil-ldl producen un incremento significativo de movilidad, por acci\u00f3n quimiocin\u00e9tica, comprobada en ensayos de checkerboard.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efectos de las lipoproteinas de baja densidad sobre los neutrofilos y sobre los cristales de acido urico.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efectos de las lipoproteinas de baja densidad sobre los neutrofilos y sobre los cristales de acido urico. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Toyos Saenz De Miera Francisco Javier <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Sevilla<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Muniain Ezcurra Miguel Angel<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Luis Mar\u00eda Ferrandez Portal <\/li>\n<li> Rubio Rubio Jos\u00e9 M. (vocal)<\/li>\n<li>Jos\u00e9 Perez Castilla (vocal)<\/li>\n<li>Eduardo Collantes Estevez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Toyos Saenz De Miera Francisco Javier Cuando los cristales de \u00e1cido \u00farico, son preincubados con diversas concentraciones [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1610,9,139,156,877,10715],"tags":[2277,10777,9591,10863,35471,94750],"class_list":["post-35506","post","type-post","status-publish","format-standard","hentry","category-arterioesclerosis-y-ateroesclerosis","category-ciencias-medicas","category-medicina-interna","category-patologia","category-reumatologia","category-sevilla","tag-eduardo-collantes-estevez","tag-jose-perez-castilla","tag-luis-maria-ferrandez-portal","tag-muniain-ezcurra-miguel-angel","tag-rubio-rubio-jose-m","tag-toyos-saenz-de-miera-francisco-javier"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/35506","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=35506"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/35506\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=35506"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=35506"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=35506"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}