{"id":35530,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-sobre-receptores-hormonales-catepsina-d-y-proteina-ps2-y-su-valor-pronostico-en-cancer-de-mama\/"},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"estudio-sobre-receptores-hormonales-catepsina-d-y-proteina-ps2-y-su-valor-pronostico-en-cancer-de-mama","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-sobre-receptores-hormonales-catepsina-d-y-proteina-ps2-y-su-valor-pronostico-en-cancer-de-mama\/","title":{"rendered":"Estudio sobre receptores hormonales, catepsina d y proteina ps2 y su valor pronostico en cancer de mama."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Pilar Azagra Ros <\/strong><\/h2>\n<p>El c\u00e1ncer de mama (cm) tiene una historia natural heterogenea, seg\u00fan la cual unas pacientes se curan \u00fanicamente con tratamiento locorregional y otras pacientes recaen y mueren por cm. La estimaci\u00f3n del riesgo de recaida en los distintos subgrupos de pacientes determinando distintos factores pron\u00f3sticos permite identificar aquellas pacientes con mayor probabilidad de recaida y muerte por cm. Aunque los factores pron\u00f3sticos en cm m\u00e1s importantes siguen siendo los relativos a la extensi\u00f3n tumoral (tama\u00f1o del tumor primario, n\u00famero de ganglios afectos, estadio), otros factores pron\u00f3sticos implicados en la biolog\u00eda de la c\u00e9lula tumoral como los receptores hormonales, la catepsina d \u00f3 la prote\u00edna ps2 pueden contribuir a la estimaci\u00f3n pron\u00f3stica a\u00f1adiendo mayor precisi\u00f3n y adecuando la elecci\u00f3n de tratamientos que optimicen los resultados terap\u00e9uticos. Desde febrero-82 a octubre-96, 2446 pacientes fueron tratadas en el h.Clinico, de las cuales en 1713 pacientes se determinaron los receptores hormonales en el tumor primario al diagn\u00f3stico. Algunas pacientes fueron remitidas por otros hospitales (general, albacete, alcoy) pero mayoritariamente fueron seguidas en el h.Cl\u00ednico de Valencia. Se analiz\u00f3 la distribuci\u00f3n de los receptores hormonales, la catepsina d, la proteina ps2, la fracci\u00f3n de c\u00e9lulas en fase s y el contenido de dna en el grupo global de pacientes intervenidas de entrada (1474), en el grupo de pacientes sin afectaci\u00f3n ganglionar (649), en el grupo de pacientes con afectaci\u00f3n ganglionar (825) y en un peque\u00f1o grupo de pacientes con cm localmente avanzado (200) e inflamatorio (39) que fueron tratadas con quimioterapia neoadyuvante. Posteriormente se analiz\u00f3 la correlaci\u00f3n de estos factores con otros de valor pron\u00f3stico establecido (edad, estado hormonal, n. De ganglios, tama\u00f1o tumoral, grado histol\u00f3gico). Luego se analiz\u00f3 su impacto pron\u00f3stico en cuanto a supervivencia libre de enfermedad (sle<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio sobre receptores hormonales, catepsina d y proteina ps2 y su valor pronostico en cancer de mama.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio sobre receptores hormonales, catepsina d y proteina ps2 y su valor pronostico en cancer de mama. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Pilar Azagra Ros <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Garc\u00eda Conde Bru Javier<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Eduardo D\u00edaz-rubio Garc\u00eda <\/li>\n<li>Antonio Ferrandez Izquierdo (vocal)<\/li>\n<li>Joaquin Ortega Serrano (vocal)<\/li>\n<li>Jos\u00e9 Sanroman Teran (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Pilar Azagra Ros El c\u00e1ncer de mama (cm) tiene una historia natural heterogenea, seg\u00fan la cual unas [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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