{"id":35573,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-del-efecto-de-primer-paso-y-del-ciclo-enterohepatico-de-la-amiodarona-en-la-rata\/"},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"estudio-del-efecto-de-primer-paso-y-del-ciclo-enterohepatico-de-la-amiodarona-en-la-rata","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-del-efecto-de-primer-paso-y-del-ciclo-enterohepatico-de-la-amiodarona-en-la-rata\/","title":{"rendered":"Estudio del efecto de primer paso y del ciclo enterohepatico de la amiodarona en la rata."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Pedro Chicano Pia <\/strong><\/h2>\n<p>Los objetivos son determinar la existencia y magnitud del efecto de primer paso hep\u00e1tico, velocidad de excreci\u00f3n biliar y ciclo enterohep\u00e1tico de la amiodarona en la rata, para lo cual, se ha dise\u00f1ado un estudio experimental, controlado y aleatorizado, mediante ensayos in vivo. Para la determinaci\u00f3n del efecto de primer paso se ha realizado un ensayo paralelo, en el que se ha administrado una dosis \u00fanica de f\u00e1rmaco a 2 grupos de animales, a uno por v\u00eda intravenosa y a otro por v\u00eda intraperitoneal, y un ensayo denominado semiparalelo, en el que se ha administrado a los animales 2 dosis de f\u00e1rmaco, una por v\u00eda intravenosa y otra por v\u00eda intraperitoneal sin per\u00edodo de lavado.  para la determinaci\u00f3n del ciclo enterohep\u00e1tico se ha realizado un ensayo paralelo, en el que se ha administrado una dosis \u00fanica de f\u00e1rmaco por v\u00eda intravenosa a 2 grupos de animales, manteniendo el ciclo funcional en uno de los grupos e interrumpi\u00e9ndolo en el otro. La amiodarona se ha valorado por cromatograf\u00eda l\u00edquida de alta eficacia. El an\u00e1lisis farmacocin\u00e9tico se ha realizado aplicando el modelo biocompartimental, obteniendo los par\u00e1metros cin\u00e9ticos mediante regresi\u00f3n no lineal por m\u00ednimos cuadrados, y el modelo no compartimental, aplicando el m\u00e9todo trapezoidal. El an\u00e1lisis de varianza de los par\u00e1metros obtenidos cuando la amiodarona se administra por v\u00eda intravenosa e intraperitoneal revela la existencia de diferencias significativas atribu\u00eddas a una p\u00e9rdida presist\u00e9mica de f\u00e1rmaco por efecto de primer paso hep\u00e1tico. La biodisponibilidad absoluta en magnitud por v\u00eda intraperitoneal es de 69% y 54% en el ensayo paralelo y semiparalelo, respectivamente. La excreci\u00f3n biliar de amiodarona es escasa y representa \u00fanicamente entre el 0,3 y 0,45% del aclaramiento plasm\u00e1tico total. El an\u00e1lisis de varianza de los par\u00e1metros farmacocin\u00e9ticos obtenidos cuando se mantiene o interrumpe el ciclo enterohep\u00e1tico indica que \u00e9st<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio del efecto de primer paso y del ciclo enterohepatico de la amiodarona en la rata.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio del efecto de primer paso y del ciclo enterohepatico de la amiodarona en la rata. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Pedro Chicano Pia <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Matilde Merino SanJuan<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Victor Jimenez Torres <\/li>\n<li>Marina Herraez Dominguez (vocal)<\/li>\n<li>Antonio Rabasco Alvarez (vocal)<\/li>\n<li>Emilio Monte Boquet (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Pedro Chicano Pia Los objetivos son determinar la existencia y magnitud del efecto de primer paso hep\u00e1tico, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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