{"id":35578,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/farmacocinetica-poblacional-de-5-fluorouracilo-en-pacientes-con-cancer-colorrectal\/"},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"farmacocinetica-poblacional-de-5-fluorouracilo-en-pacientes-con-cancer-colorrectal","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/farmacocinetica-poblacional-de-5-fluorouracilo-en-pacientes-con-cancer-colorrectal\/","title":{"rendered":"Farmacocinetica poblacional de 5-fluorouracilo en pacientes con cancer colorrectal."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Monica Climente Marti <\/strong><\/h2>\n<p>Se ha realizado un estudio farmacocin\u00e9tico poblacional de 5-fluorouracilo, administrado en perfusi\u00f3n intravenosa de corta duraci\u00f3n (30-60 minutos), en pacientes adultos con c\u00e1ncer colorrectal. Los objetivos han sido caracterizar los par\u00e1metros farmacocin\u00e9ticos poblacionales del f\u00e1rmaco y su variabilidad, tr\u00e1s la administraci\u00f3n de dosis \u00fanica y dosis m\u00faltiples, e identificar y evaluar la influencia de diferentes predictores sobre estos par\u00e1metros, con el objeto de establecer un modelo bayesiano que permita predecir las concentraciones plasm\u00e1ticas del f\u00e1rmaco con exactitud y precisi\u00f3n. La poblaci\u00f3n total consta de 44 pacientes, que han sido divididos en un grupo de estimaci\u00f3n y un grupo de validaci\u00f3n para cada modelo.  para el an\u00e1lisis farmacocin\u00e9tico poblacional se ha utilizado el m\u00e9todo est\u00e1ndar en dos etapas, el modelo no lineal de efectos mixtos y el m\u00e9todo no param\u00e9trico. La toma de muestras de sangre se ha realizado 10, 30 y 60 minutos postperfusi\u00f3n. Los resultados han identificado la concentraci\u00f3n obtenida 10 minutos postperfusi\u00f3n como la que permite predecir el resto de concentraciones con mayor exactitud y precisi\u00f3n, tanto en el modelo de dosis \u00fanica como de dosis m\u00faltiples.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Farmacocinetica poblacional de 5-fluorouracilo en pacientes con cancer colorrectal.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Farmacocinetica poblacional de 5-fluorouracilo en pacientes con cancer colorrectal. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Monica Climente Marti <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Victor Jimenez Torres<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Adela Mart\u00edn Villodr\u00e9 <\/li>\n<li>Andr\u00e9s Cervantes Ruiperez (vocal)<\/li>\n<li>Irene Molina Martinez (vocal)<\/li>\n<li>Mar\u00eda De La Paloma Ballesteros Papantonakis (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Monica Climente Marti Se ha realizado un estudio farmacocin\u00e9tico poblacional de 5-fluorouracilo, administrado en perfusi\u00f3n intravenosa de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9481,9,189],"tags":[12340,51289,17650,6886,94881,3309],"class_list":["post-35578","post","type-post","status-publish","format-standard","hentry","category-absorcion-de-los-farmacos","category-ciencias-medicas","category-farmacodinamia","tag-adela-martin-villodre","tag-andres-cervantes-ruiperez","tag-irene-molina-Martinez","tag-maria-de-la-paloma-ballesteros-papantonakis","tag-monica-climente-marti","tag-victor-jimenez-torres"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/35578","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=35578"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/35578\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=35578"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=35578"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=35578"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}