{"id":35593,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-farmacologico-de-la-regulacion-de-la-fosfodiesterasa-4-en-neutrofilos-humanos\/"},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"estudio-farmacologico-de-la-regulacion-de-la-fosfodiesterasa-4-en-neutrofilos-humanos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-farmacologico-de-la-regulacion-de-la-fosfodiesterasa-4-en-neutrofilos-humanos\/","title":{"rendered":"Estudio farmacologico de la regulacion de la fosfodiesterasa 4 en neutrofilos humanos."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Dasi Fernandez Francisco Jose <\/strong><\/h2>\n<p>Estudios previos realizados con c\u00e9lulas u937, una l\u00ednea celular de monocitos humanos, demuestran que el tratamiento prolongado con agentes que aumentan los niveles de ampc incrementan, en dichas c\u00e9lulas, la actividad pde4. En nuestro trabajo se emplearon neutr\u00f3filos humanos, los cuales es incubaron durante 4 hrs. A 37 grados cent\u00edgrados, por una parte con una combinaci\u00f3n de salbutamol y rolipram para producir un aumento prolongado de los niveles de ampc intracelular y como consecuencia un incremento de la catividad pde4, y por otra parte con histamina con el fin de poder determinar su posible papel en la regulaci\u00f3n de la actividad pde4. Tras estos tratamientos se utilizaron inhibidores espec\u00edficos de la pde4 para caracterizar los perfiles de actividad pde en condiciones basales y tr\u00e1s los diversos tratamientos. Estos experimentos demostraron que el aumento de la actividad pde se produce como consecuencia de una inducci\u00f3n de la expresi\u00f3n de los diferentes isogenes de la pde (determinada mediante rt-pcr), produci\u00e9ndose un aumento de la expresi\u00f3n de los isogenes pde4a y pde4b tras el tratamiento con salbutamol y rolipram y \u00fanicamente del isog\u00e9n pde4a tras el tratamiento con histamina, no observ\u00e1ndose modificaciones de la expresi\u00f3n de los isogenes pde4c ni pde4d. Desde el punto de vista funcional, el aumento de la actividad pde4 disminuye la capacidad de la pge2 para inhibir la generaci\u00f3n de ani\u00f3n super\u00f3xido inducida por zimos\u00e1n.  todas las pruebas anteriormente descritas se realizaron en neutr\u00f3filos provenientes de sangre de pacientes asm\u00e1ticos tratados durante periodos prolongados con agonistas beta 2, observ\u00e1ndose resultados similares a los obtenidos tras las incubaciones con salbutamol y rolipram y con histamina.  estos resultados nos permiten concluir que existe una regulaci\u00f3n diferencial de los isogenes de la pde4 tras los tratamientos que producen un aumento prolongado de ampc. Una posible consecuenci<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio farmacologico de la regulacion de la fosfodiesterasa 4 en neutrofilos humanos.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio farmacologico de la regulacion de la fosfodiesterasa 4 en neutrofilos humanos. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Dasi Fernandez Francisco Jose <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Julio Cortijo Gimeno<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Morcillo Sanchez Esteban Jes\u00fas <\/li>\n<li>Roger Marthan (vocal)<\/li>\n<li>Francisco Paris Romeu (vocal)<\/li>\n<li>Ramon Rodriguez Rossin (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Dasi Fernandez Francisco Jose Estudios previos realizados con c\u00e9lulas u937, una l\u00ednea celular de monocitos humanos, demuestran [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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