{"id":35645,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudi-de-la-resposta-inmunologica-local-i-sistemica-a-la-profilaxi-de-les-recidives-dels-tumors-vesicals-superficials-amb-bcg-tiotepa-i-interfero-alfa-2-b\/"},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"estudi-de-la-resposta-inmunologica-local-i-sistemica-a-la-profilaxi-de-les-recidives-dels-tumors-vesicals-superficials-amb-bcg-tiotepa-i-interfero-alfa-2-b","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudi-de-la-resposta-inmunologica-local-i-sistemica-a-la-profilaxi-de-les-recidives-dels-tumors-vesicals-superficials-amb-bcg-tiotepa-i-interfero-alfa-2-b\/","title":{"rendered":"Estudi de la resposta inmunologica local i sistemica a la profilaxi de les recidives dels tumors vesicals superficials amb bcg, tiotepa i interfero alfa-2 b."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Stefan Gunthner <\/strong><\/h2>\n<p>Objetivos:  1) caracterizar las subpoblaciones leucocitarias en carcinomas de c\u00e9lulas transicionales (cct) superficiales y en la mucosa vesical normal 2) comparar la respuesta local y sist\u00e9mica producida por el tratamiento intravesical con bcg 81 mg. Bcg 27 mg. Thiotepa 50 mg.  (ttp) bcg y interferona alfa-2b (ifn).  material y m\u00e9todos:  55 pacientes con cct superficiales. Profilaxis de recidivas con 6 instilaciones intravesicales semanales y 10 mensuales de bcg 81 mg.(N=16), bcg 27 mg. (N=15), ttp (n=15) y ifn (n=9) biopsias vesicales y muestras de sangre perif\u00e9rica al inicio, a las 6 semanas, a los 6 meses.  inmunohistoqu\u00edmica de biopsias vesicales para linfocitos t, t4, t8, b, macr\u00f3fagos, c\u00e9lulas nk, receptores il-2 y hla-dr. Citometria de flujo para linfocitos t, t4, t8, b, c\u00e9lulas nk y linfocitos t hla-dr (+).  aumento del infiltrado de macr\u00f3fagos, linfocitos t i t4 en los cct superficiales respecto del urotelio normal.  incrementos significativos (p 0,05) en todas las poblaciones mononucleares estudiadas a nivel local en los tratamientos bcg 81 mg. Bcg 27 mg. Y thiotepa. No se observan cambios significativos con el tratamiento ifn.  histol\u00f3gicamente se observa un patr\u00f3n inflamatorio diferente para ifn, ttp(difuso) y bcg(folicular). No hay diferencias en la respuesta inflamatoria entre bcg dosis est\u00e1ndard (81mg) y bcg dosis reducida (27 mg).  la respuesta inflamatoria local es mayor en los pacientes con buena evoluci\u00f3n. En el estudio de poblaciones mononucleares en sangre perif\u00e9rica no se observan cambios relacionados con la respuesta local a los tratamientos.  se observan 13 recidivas (ifn: 7\/9; ttp: 4\/15; bcg 27mg:  0\/15; bcg 81 mg: 2\/16).  conclusiones:  los cct provocan una reacci\u00f3n end\u00f3gena antitumoral local de c\u00e9lulas mononucleares con predominio de macr\u00f3fagos y linfocitos t. La respuesta local al tratamiento con ttp y bcg es equivalente por criterios inmunohistoqu\u00edmicos pero con difer<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudi de la resposta inmunologica local i sistemica a la profilaxi de les recidives dels tumors vesicals superficials amb bcg, tiotepa i interfero alfa-2 b.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudi de la resposta inmunologica local i sistemica a la profilaxi de les recidives dels tumors vesicals superficials amb bcg, tiotepa i interfero alfa-2 b. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Stefan Gunthner <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Fernandez Sanchez De Sevilla M. Carmen<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Pablo Carretero Gonz\u00e1lez <\/li>\n<li>Ferran Algaba Arrea (vocal)<\/li>\n<li>Antonio Llombart Bosch (vocal)<\/li>\n<li>Eduardo Solsona Narbon (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Stefan Gunthner Objetivos: 1) caracterizar las subpoblaciones leucocitarias en carcinomas de c\u00e9lulas transicionales (cct) superficiales y en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[155,9,450,156,971],"tags":[12285,95003,95002,84107,1046,95001],"class_list":["post-35645","post","type-post","status-publish","format-standard","hentry","category-ciencias-clinicas","category-ciencias-medicas","category-inmunopatologia","category-patologia","category-urologia","tag-antonio-llombart-bosch","tag-eduardo-solsona-narbon","tag-fernandez-sanchez-de-sevilla-m-carmen","tag-ferran-algaba-arrea","tag-pablo-carretero-gonzalez","tag-stefan-gunthner"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/35645","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=35645"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/35645\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=35645"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=35645"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=35645"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}