{"id":35875,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/los-factores-neurotroficos-en-el-desarrollo-de-las-neuronas-cocleovestibulares-transferencia-de-genes-mediante-vectores-basados-en-el-virus-herpes\/"},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"los-factores-neurotroficos-en-el-desarrollo-de-las-neuronas-cocleovestibulares-transferencia-de-genes-mediante-vectores-basados-en-el-virus-herpes","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/los-factores-neurotroficos-en-el-desarrollo-de-las-neuronas-cocleovestibulares-transferencia-de-genes-mediante-vectores-basados-en-el-virus-herpes\/","title":{"rendered":"Los factores neurotroficos en el desarrollo de las neuronas cocleovestibulares: transferencia de genes mediante vectores basados en el virus herpes."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Garrido Jurado Juan  Jose <\/strong><\/h2>\n<p>Las neuronas cocleovestibulares transmiten los est\u00edtulos auditivos desde el epitelio sensorial del o\u00eddo interno hasta el sistema nervioso central. El desarrollo de las neuronas cocleovestibulares y la interacci\u00f3n con el epitelio sensorial est\u00e1 regulado por factores neurotr\u00f3ficos.  los resultados obtenidos muestran que las neuronas cocleares y las vestibulares dependen del bdnf para su supervivencia. Esta dependencia se adquiere a los 7 d\u00edas de desarrollo y la respuesta neuritog\u00e9nica es m\u00e1xima a los 8 d\u00edas. En estadios posteriores la respuesta de bdnf disminuye y es muy d\u00e9bil a los 15 d\u00edas de desarrollo.  la transferencia de los genes de las neurotrofinas y sus receptores mediante vectores v\u00edricos basados en el virus herpes permite una eficaz expresi\u00f3n de los mismos. Los resultados muestran que las neuronas cocleares sobreviven al ser infectadas con un virus bdnf.  el estudio muestra que las neuronas cocleares no dependen del ngf para su supervivencia. La transferencia del gen de su receptor de alta afinidad, trka, permite generar una respuesta biol\u00f3gica al ngf.  el fgf b\u00e1sico se expresa en el epitelio sensorial vestibular y es un factor de supervivencia para las neuronas vestibulares en estadios de desarrollo posteriores a los de actuaci\u00f3n de bdnf (12 y 13 d\u00edas) y ambos factores (bdnf y fgfb) tienen efectos aditivos en el mantenimiento de la supervivencia hasta los 13 d\u00edas de desarrollo de las neuronas vestibulares.  el hecho de que a partir del d\u00eda 14 de desarrollo estos factores no mantengan la supervivencia de las neuronas cocleares y vestibulares sugiere la necesidad de una interacci\u00f3n funcional con el epitelio sensorial.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Los factores neurotroficos en el desarrollo de las neuronas cocleovestibulares: transferencia de genes mediante vectores basados en el virus herpes.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Los factores neurotroficos en el desarrollo de las neuronas cocleovestibulares: transferencia de genes mediante vectores basados en el virus herpes. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Garrido Jurado Juan  Jose <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Valladolid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Fernando Gir\u00e1ldez Orgaz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Constancio Gonzalez Mart\u00ednez <\/li>\n<li>Pablo Gil Loyzaga (vocal)<\/li>\n<li>Filip Lim (vocal)<\/li>\n<li>Isabel Varela Nieto (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Garrido Jurado Juan Jose Las neuronas cocleovestibulares transmiten los est\u00edtulos auditivos desde el epitelio sensorial del o\u00eddo [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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