{"id":35912,"date":"1998-01-01T00:00:00","date_gmt":"1998-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/alergenos-de-harina-de-centeno-y-su-importancia-clinica\/"},"modified":"1998-01-01T00:00:00","modified_gmt":"1998-01-01T00:00:00","slug":"alergenos-de-harina-de-centeno-y-su-importancia-clinica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/alergenos-de-harina-de-centeno-y-su-importancia-clinica\/","title":{"rendered":"Alergenos de harina de centeno y su importancia clinica."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Mendez Alcalde Jorge  Dario <\/strong><\/h2>\n<p>La sensibilizaci\u00f3n a harina de cereales es una causa frecuente de enfermedades alergicas. Se ha realizado un estudio sobre la importancia de algunas proteinas purificadas de la harina de centeno como alergenos causantes de sensibilizaci\u00f3n al\u00e9rgica, comparando su alergenicidad con la de sus proteinas hom\u00f3logas en trigo y cebada. Seleccionamos 21 pacientes sensibilizados a harina de centeno a los que se realiz\u00f3 pruebas cutaneas en prick, provocaci\u00f3n conjuntival y bronquial espec\u00edfica y determinaci\u00f3n de ige mediante rast utilizando para todas las pruebas un extracto comercial de harina de trigo, cebada y centeno; tambi\u00e9n se realiz\u00f3 prick e inmunodetecci\u00f3n mediante dot blot con 2 proteinas purificadas de trigo (wtai-cm2, wdai), 2 de cebada (bmai-1, bdp) y 5 de centeno (r-1, r-2, r-3, rdai-1, sec c 1). La caracterizaci\u00f3n y purificaci\u00f3n de proteinas de centeno y de sus hom\u00f3logas en trigo y cebada se realiz\u00f3 mediante extracci\u00f3n en cloruro s\u00f3dico, precipitaci\u00f3n en sulfato am\u00f3nico, filtraci\u00f3n en gel de sephadex, cromatograf\u00eda por hplc-rp y comprobaci\u00f3n de la purificaci\u00f3n mediante sds-page e ief-bd. Se efectu\u00f3 un test de detecci\u00f3n de glicoproteinas y de capacidad de inhibici\u00f3n de distintas alfa-amilasas con las proteinas purificadas de centeno. Todos los pacientes ten\u00edan ige espec\u00edfica a harina de centeno, mas del 50% de los pacientes estaban sensibilizados a otros alergenos, una proteina de centeno (sec c 1) se considera el alergeno mayor de la harina de centeno, ninguna de las proteinas de centeno est\u00e1 glicosilada y sin embargo se las considera que forman parte de la familia de proteinas inhibidoras de alfa-amilasa\/tripsina. Se obtuvo un coeficiente de correlaci\u00f3n muy significativo (p&lt;0.001) al correlacionar los resultados de las pruebas cutaneas y de inmunodetecci\u00f3n de todas las proteinas purificadas. Las especificidades inhibitorias de alfa- amilasa, comportamiento de agregaci\u00f3n, patrones de glicosilaci<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Alergenos de harina de centeno y su importancia clinica.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Alergenos de harina de centeno y su importancia clinica. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Mendez Alcalde Jorge  Dario <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Valladolid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Alicia Armentia Medina<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Vicente Herreros Fernandez <\/li>\n<li> Arranz Pe\u00f1a M. Luisa (vocal)<\/li>\n<li>Felix Lorente Toledano (vocal)<\/li>\n<li> Carretero Sastre Jos\u00e9 Luis (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mendez Alcalde Jorge Dario La sensibilizaci\u00f3n a harina de cereales es una causa frecuente de enfermedades alergicas. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1957,35,9,1737,156,1775,12451],"tags":[27788,95475,12543,14979,95474,12485],"class_list":["post-35912","post","type-post","status-publish","format-standard","hentry","category-alergias","category-ciencias-de-la-vida","category-ciencias-medicas","category-inmunologia","category-patologia","category-reaccion-antigeno-anticuerpo","category-valladolid","tag-alicia-armentia-medina","tag-arranz-pena-m-luisa","tag-carretero-sastre-jose-luis","tag-felix-lorente-toledano","tag-mendez-alcalde-jorge-dario","tag-vicente-herreros-fernandez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/35912","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=35912"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/35912\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=35912"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=35912"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=35912"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}